The Association Of TNFSF15 Genetic Variant With The Susceptibility To Larynx Cancer

Objectives Todiscuss the Association of TNFSF15 genetic variant with the susceptibility to Larynx cancer. Provided theory basis for the future to prevent the pathogenesis of carcinoma of larynx and target gene therapy.Methods Using the method of case- control study, collected cases of laryngeal cancer from tianjin, tangshan areas. 169 cases carcinoma of larynx patients were selected as experimental groups, 338 cases were selected as healthy controls. PCR-RFLP method was used to detect the mutation genotype of TNFSF15-638A>G. Through the method of querying the case, we got the epidemiological data of the research object. Chi-square test was used to compare each genotype of the site in the distribution of the difference between the case group and the control group, unconditioned Logistic regression method was used to calculate adjustment of gender and OR value of age(95% CI). Analyzing the relationship between gene polymorphism and laryngeal cancer risk, as well as the roles of factors such as age and gender to genetic variation in the interaction on the pathogenesis of laryngeal cancer.Results Results of Logistic regression analysis showed that individuals carrying at least one-638 AG and-638 GG genotype had relative risk reduction in laryngeal cancer, compared with the individuals with TNFSF15-638 AA genotype. The OR values were 0.608(95%CI=0.395~0.936) and 0.395(95%CI=0.368~1.045), respectively. Gender and agehierarchical analysis showed that the onset risk of men who carried-638 AG genotype was decreased 0.555(95%CI=0.346~0.889) when compared with the men carrying with TNFSF15-638 AA genotype. The onset risk of- 638 GG genotype female carriers could significantly decrease. The laryngeal cancer risksof AG genotype carriers less than 61 and more than 61 years old were down significantly when compared with-638 AA genotype carriers less than 61 years old. The OR values were 0.377 and 0.425(95%CI=0.205~0.692,0.205 ~ 0.880), respectively. The onset risk of GG genotype carriers less than 61- year-old was also decreased(OR = 0.543, 95%CI = 0.292~1.010).Conclusions There was a correlation between TNFSF15 gene polymorphism and the occurrence of carcinoma of larynx. TNFSF15-638 A>G genetic variation genetic variation of G allele was the protective factor to the occurrence of carcinoma of larynx. The interaction existed between gender factors and TNFSF15-638 A>G genetic variation.