Therapeutic Effect Of Nephron-sparing Management For Low-grade Upper Tract Urothelial Carcinomas: A Meta Analysis

ObjectiveTo compare the therapeutic effects of nephron-sparing management versus radical nephroureterectomy management for low-grade upper tract urothelial carcinomas.MethodsLiterature on the therapy of low-grade upper tract urothelial carcinoma by nephron-sparing management or radical nephroureterectomy management were collected from Pubmed, Springer, Science Direct, WANFANG, CNKI and CBM. Meta analysis was conducted for the date about the 5-year survival rate and disease-specific survival rate,collected according to Cochrane Collaboration.ResultsA total of 6 studies including 436 patients were identified and analyzed. The results showed no significant differences in the 5-year survival rate(RR=0.95, 95%CI= 0.61~1.48,P>0.05) and 5-year disease-specific survival rate(RR=0.83, 95%CI= 0.42~1.64, P> 0.05).ConclusionA comparison between nephron-sparing management and radical nephroureterectomy management for low-grade upper tract urothelial carcinomas shows no significant differences in terms of 5-year survival rate and 5-year disease-specific survival rate, and has the same therapeutic effect;But the injury of the former is low, so the clinicians could selectively use nephron-sparing management according to the individual differences of patients.