The Clinical Correlative Study Of Plasma Homocysteine Level And Blood Glucose In Coronary Artery Heart Disease

Objective:To observe the concentration of homocysteine(homocysteine Hcy), glycosylated hemoglobin(GHb A1c),and acute blood glucose change in coronary heart disease(CHD)patients and the influence of prognosis in CHD patients by three parameters. Methods:The medical records of the 219 patients in cardiology of changzhi city people’s hospital were collected during 2013.Blood sugar,fasting plasma homocysteine and glycated hemoglobin(GHb A1c)were detected when they had been hospitalized,coronary angiography and disease evolution were recorded while in hospital.The patients were divided into four groups according to the severity of coronary angiography,to analysis of different severity of coronary lesions and the relationship among the three factors.According to the different illness,the patients were divided into three groups,compare the relationship between coronary heart disease severity and the three research factors.The data were deal with SPSS 20.0,continuous variables with(sx ±)and p<0.05 as was statistically significant.Results:According to the results of coronary angiography,blood glucose in coronary angiography negative group was lower than multivessel lesion group(p<0.05),but coronary angiography negative group,one lesion group and two lesions group’s blood glucose were no statistically significant(p>0.05),there was no statistically significant between one lesion,two lesions and multivessel lesions group(p>0.05).Glycated hemoglobin in Negative group was lower than others(p<0.05),one lesion and two lesions group were lower than multivessel lesions(p<0.05),but there was no statistically significant between one lesion and two lesions group(p>0.05).Homocysteine in negative group was lower than other groups(p<0.05),one lesion group and two lesions group were lower than multivessel lesion group(p<0.05),but pathological changes were no statistically significant(p>0.05).Accorded to the severity of coronary heart disease,immediate admission blood glucose was differences between mild,moderate group and severe(p<0.05),from low to high for mild, moderate,and severe.Homocysteine levels between mild and moderate was no difference(p>0.05),but the mild group and moderate group were lower than severe(p<0.05).Glycosylated hemoglobin had differences between the three groups(p<0.05),from low to high for mild,moderate and severe.Immediate admission blood glucose has nothing to do with the homocysteine(p=0.732),and glycosylated hemoglobin moderate positive correlation(r=0.765, p<0.01),glycosylated hemoglobin and homocysteine as low positive correlation(r=0.311, p=0.023).The data showed higher homocysteine levels,glycosylated hemoglobin and acute hyperglycemia were risk factors for coronary heart disease,but gender such as women were protective factors.Diabetes,high homocysteine,abnormal glycosylated hemoglobin and acute hyperglycemia were risk factors for coronary heart disease(CHD) in the near future outcome. Conclusions:The important influence factors of coronary heart disease were Homocysteine levels,glycosylated hemoglobin,immediate admission blood glucose coronary artery lesions and coronary heart disease.It’s very useful to detect these three variables and positive intervention during diagnostic and treatment process for coronary heart disease patients.