The Correlation Between HBV Infection And Other Diseases

Objective:In this study, we aim at probing into the clinical features of hepatitis B virus infection in the patients with rheumatic diseases, endocrine diseases, and haematological diseases,and demonstrate the relevance between HBV infection and other diseases.Participants and Methods:We selected 3387 patients who were diagnosed with multiple myeloma, aplastic anemia, lymphoma, ankylosing spondylitis, rheumatoid arthritis, systemic lupus erythematosus(SLE), type 2 diabetes, and Grave’s disease. We classified the patients as study group, and 914 healthy people as control group. All patients and controls were from the second hospital of Shanxi medical college between 2012.11.01 and 2014.11.01.Results:1. The positive rate of HBs Ag in control group is 2.5%.2. The positive rate of HBs Ag in patients with lymphoma is 7.8%, with type 2 diabetes is6.3%, with multiple myeloma is 5.0%, with aplastic anemia is 5.0%, with Graves disease is 3.4%, with ankylosing spondylitis is 2.3%, with rheumatoid arthritis is 1.4%,with systemic lupus erythematosus is 1.2%.3. The positive rates of HBs Ag in patients with lymphoma, multiple myeloma, aplastic anemia and type 2 diabetes are higher than healthy control group and the difference was statistically significant.4. Chi-square test was used for the titers of HBs Ag in patients with lymphoma, type 2diabetes, aplastic anemia and multiple myeloma(P>0.05) and the difference was not statistically significant.5. Around treatment, the incidence of liver damage in patients with both multiple myeloma or lymphoma and HBVinfection is higher than patients without HBV infection, but the difference was not statistically significant but the titers of HBs Ag had no significant differences.6. In the group of patients with lymphoma and HBV infection, no matter with or without hepatic damage, the HBs Ag levels remained the same before and after treatment.7. The positive rate of HBs Ag with Graves disease is higher than healthy control group but the difference was not statistically significant.8. The positive rates of HBs Ag in patients with ankylosing spondylitis, rheumatoid arthritis and systemic lupus erythematosus are lower than healthy control group but the differences was not statistically significant.9. The positive rate of HBs Ag in patients with ankylosing spondylitis(HLA-B27+) is higher than without HLA-B27 but the difference was not statistically significant.Conclusions:1. HBV infection is one of the risk factors for lymphoma, multiple myeloma, aplastic anemia and type 2 diabetes.2. HBV infection is not significantly related with Graves disease, ankylosing spondylitis,rheumatoid arthritis and systemic lupus erythematosus.3. The incidence of liver damage may be independent of the titers of HBs Ag in patients with lymphoma and multiple myeloma and chemotherapy has no effect on the titers of HBs Ag.4. The infection of HBV may be independent of Graves disease, ankylosing spondylitis,rheumatoid arthritis and systemic lupus erythematosus.5. Whether the positive rate of HBs Ag relates to the HLA-B27 genotype of ankylosing spondylitis is not clear.