Correlation Of Cystatin C And Diabetic Retinopathy In Type 2 Diabetic Patients

Objective:To analyze the correlation of cystatin C and diabetic retinopathy in type2 diabetic Patients.Methods:Record patients′gender、age、diabetes duration,measure the SBP、DBP,and measure the height、weight to calculate body mass index(BMI)=weight(kg)/height(m2);Serum cystatin C levels, estimated glomerular filtration rate(GFR);detect the fasting plasma glucose(FPG) 、 2h postprandial blood glucose(2h PG) 、 triglyceride(TG) 、glycosylated hemoglobin(Hb A1c)、low-density lipoprotein(LDL-C)、creatinine、total cholesterol(TC) 、 urea nitrogen 、 high-density lipoprotein(HDL-C) and the fasting c-peptide(FC-P) 、 postprandial 2h c-peptide(2h C-P) under the standard steamed bread meal test, all subjects were measured by immunoturbidimetry in group A(60 type 2diabetic patients with retinopathy) and group B(60 type 2 diabetic patients without retinopathy) in resting state on an empty stomach.Exam the retina by an ophthalmologist direct ophthalmoscope,fundus fluorescence angiography on occasion.Results:(1) The comparion of the general clinical data and the level of cystatin c between the two groups(table 1):The age、BMI、TC、TG、HDL-C、LDL-C、blood urea nitrogen、serum creatinine、systolic blood pressure、FC-P、2h C-P、FPG、2h PG of the teo groups have no statistically significant difference(P>0.05); The glomerular filtration rate 、diastolic blood pressure、diabetes duration、 serum cystatin C level and Hb A1 c of group A was higher than those of group B(P<0.05).(2) The correlation analysis between cystatin c level with the general dinicaland biochemical index: the results show that cystatin c level of serum was positively correlated(P<0.05 或 P< 0.01) with age(r=0.377)、Hb A1c(r=0.176)、creatinine(r=0.44)、blood urea nitrogen(r=0.534),and has no obvious correlation with BMI 、 TG 、 TC 、HDL-C、LDL-C、systolic blood pressure、diastolic blood pressure、FPG、2h PG、FC-P、2h C-P、diabetes duration.(3) Logistic multiple regression analyze the risk factors of diabetes retinopathy of the patients with type 2 diabetes(table 2):take whether have retinopathy as the dependent variable,take diabetes duration、glomerular filtration rate、diastolic blood pressure、Hb A1c、serum cystatin C level as independent variable,and then conduct the regression analysis.The results show that Cys C(OR=0.104,95%CI0.028-0.386,P<0.05)、diabetes duration(OR=0.892,95 % CI0.840-0.946,P<0.05) 、 Hb A1c(OR=0.639,95 %CI0.512-0.798,P<0.05)、diastolic blood pressure(OR=0.958,95%CI0.922-0.996,P<0,05)are the determinants of diabetic retinopathy in type 2 diabetic patients, namely cystatin c 、 Hb A1 c diastolic blood pressure are higher,or diabetes duration is longer,,having diabetes retinopathy is easier.Conclusion:The level of serum cystatin C may play a vital part in early prevention、diagnosis and treatment of diabetic retinopathy.Cystatin C、Hb A1 c diastolic blood pressure are higher,or diabetes duration is longer, having diabetes retinopathy is easier.