| Objective: To explore the relationship between ultrasonographic characteristics, mammographic features and expression of ER, PR and Her-2 in breast ductal carcinoma in situ(DCIS).Methods: The clinical, pathological, ultrasonographic, Mammographic data of 49 cases of DCIS from January 2010 to June 2014 in the First Affiliat ed Hospital of Shihezi University of Xinjiang Province were retrospectively analyzed.χ2 test was used to detect the correlation among age, ultrasonographic characteristics, mammographic features with the expression of ER,PR and Her-2. Fisher’s exact test was used to detect the correlation between the diameter of mass and the expression of ER,PR and HER-2.Results:1.The sonographic characteristics were non-mass group in 17cases(34.69%,17/49),which included partial dense glands and architecture disorder in 3 cases(6.12%,3/49),simply dilated ducts in 4 cases(8.16%, 4/49),dilated ducts with low-weak echo in 1case(2.04%,1/49),and no specific features in 9 cases(18.37%,9/49). The sonographic characteristics were mass group in 32 cases(65.31%,32/49),which included lumps in 11 cases(22.45%, 11/49), lumps with calcification in 18 cases(36.73%,18/49), dilated ducts with cystic-solid nodule in the end in 3 cases(6.12%,3/49).ER,PR and Her-2 positive rate were 81.25%(26/32), 87.50%(28/32),68.76%(22/32) respectively in sonographic mass group of DCIS.ER and PR positive rate were both 8/17. Her-2 positive rate was 10/17 in sonographic non-mass group of DCIS.ER and PR positive rate of DCIS in sonographic mass group were signif icantly higher than in sonographic non-mass group. ER and PR positive rate of the two groups were both statistically significant, and there was significantly different(χ2=6.110,P=0.013;χ2=7.356,P=0.007).While there was not statistically different in Her-2 positive rate of the two groups(χ2=0.483,P=0.487).2.The mammographic features were calcification group in 33 cases(33/49,67.34%), which included local asymmetric dense gland with calcification in 4 cases(4/49,8.16%),nodules with calcification in 9 cases(9/49, 18.37%),pure calcifications in 20 cases(20/49,40.82%). The mammographic features were non-calcification group in 16 cases which included local asymmetric dense gland in 3 cases(3/49, 6.12%), nodules in 3 cases(3/49, 6.12%), and no specific features in 10 cases(10/49, 20.41%).ER,PR and Her-2 positive rate were 60.61%(20/33),75.76%(25/33),75.76%(25/33) respectively in mammographic calcification group of DCIS. ER,PR and Her-2 positive rate were 14/16、11/16、7/16 in mammographic non-calcification group of DCIS,Her-2 positive rate in mammographic calcification group was significantly higher than in mammographic non-calcification group.Her-2 positive rate of the two groups was statistically signif icant, and there was signif icantly different(χ2=4.872,P=0.027).While there was not different in ER,PR positive rate of the two groups( χ2=2.512,P=0.113;χ2=0.031,P=0.860). 3. The sonographic findings were calcification in 17 cases which were all f ine-dot light points within the lumps; The mammographic features were calcification group in 33 cases which include pure calcifications in 20 cases. The cases of calcification found in ultrasound accounted for 54.54% of the number of cases found in mammography.Conclusion: In this study, ultrasonographic characteristics and mammographic features of DCIS are varied. According to the ultrasonographic characteristics and mammographic features of DCIS can indirectly infer the expression of ER,PR,Her-2.DCIS of sonographic mass group was more likely to be positive ER, PR status which may be an indicator of good prognosis. DCIS of mammographic calcification group was more likely to be positive HER-2 status which may be an indicator of the risk of recurrence. In some cases, it can correctly evaluate biological behavior and prognosis of DCIS and provide important references to clinical diagnosis and individualized treatment. |
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