A Study Of The Correlation Between The Change Of Serum Inflammatory Factors And The Clinical Characters On Post-traumatic Stress Disorder Of Tumor Patients

1. Objective:To explore the correlation between the change of immunocompetence and monoamine neurotransmitter level on post-traumatic stress disorder of tumor patients.2. Methods:The PTSD group was consist of 31 participants who experienced tumor, without other physical injuries and met the standard of Diagnostic and Statistical of Mental Disorders(DSM—IV).The non-PTSD group was consist of 60 participants who experienced tumor. Participants were tumor survivors which were recruited from the affiliated hospital of He Bei University(Psychological rehabilitation division, Emergency surgery, Neurosurgery, Department of burn, Orthopaedics).The normal control group was consist of 30 health persons, who were matched with experimental groups for age, sex and race. All the participants of experimental groups who experienced tumor were enrolled into the present study, including patients who met the diagnosis of PTSD and individuals who didn’t. We evaluated both demographic date within three months after the tumor happened and PCL-C scale within two days that participants were enrolled into the group. If the score is more than 41, the participants will be assessed by two psychiatric clinicians together.The cytokines(Interleukin IL- 2, IL- 6, tumor necrosis factor TNF – a) of all the participants were detected with AEC-ELISA by use of Enzyme-linked immunosorbent which was provided by the biological technology of west don of Shanghai.Use two independent samples nonparametric rank analyzed the date that do not conform to the normal distribution. Correlation analysis including Pearson correlation analysis was used when the date conform to the normal distribution and spearman correlation analysis was used when the date do not conform to the normal distribution.(Two-sided significance level 0.05)3. Results:(1) There were significant differences among the PTSD group, the non- PTSD group and the normal control group of levels(p<0.05).(2) The expression levels of IL- 2, IL- 6 and TNF-a in the PTSD group were found obviously higher than the non-PTSD group, while the levels of IL- 2, IL- 6 and TNF-a in the two experimental groups were significantly higher than the normal control(p<0.05).(3) Correlation analysis demonstrated that there was a positive correlation between the PCL-C scores and the expression levels of IL- 2, IL- 6 and TNF-a(R=0.306, 0.219 and 0.271 respectively; p<0.05). Before and after treatment, cytokines of n-PTSD group were obviously higher than PTSD group, indicating that PTSD is a negative factor for the prognosis of tumor treatment.4. Conclusions:In the patients with malignancy, the incidence of PTSD is higher than normal people in the present study. Besides, there was a positive correlation between the PTSD and the expression levels of IL- 2, IL- 6 and TNF-a in the cancer patients, indicating that cytokines may play as a important mediator in the course of cancer with PTSD. In a word, the biological indicators above described need to be further researched about the pathogenesis and the prevention of PTSD.