Relationship Between Acute PTE And Activity Change Of Plasma Protein C,Protein S And Antithrombin Ⅲ

Objective : To explore association of activity change of Protein C(PC), Protein S(PS),Antithrombin Ⅲ(AT-Ⅲ) in patients with Pulmonary Tromboembolism(PTE). To explore the plasma protein C(PC),protein S(PS),antithrombin Ⅲ(AT-Ⅲ) activity characteristic in patients with acute pulmonary thromboembolism(PTE) relationship between acute PTE and activity change of plasma Protein C,Protein S, Antithrombin Ⅲ,and the effect of PC, PS, AT-Ⅲ on formation of PTE.Method:There were three groups in this study,60 PTE patients’ group, 55 high-risk-factor patients’ group and 60 control subjects.We determined the implication in activities of PC and AT-Ⅲ by chromogenic substrate method, and PS by clotting method. Subjects in the three groups were scored and stratified( divided into high risk level, middle risk level,low risk level and very low risk level) according to Venous Thromboembolism(VTE) risk factor by Caprini Score Risk Assessment Model. Count data using rank test,Measurement data using analysis of variance. Influences on PTE by PC, PS, AT-Ⅲ were analysed by Logistic regression.Result:The activities of PC,PS and AT-Ⅲ in the PTE patients’ group and high-risk-factor patients’ group were significantly lower than control subjects(P<0.01),Whereas there were no significant differences in the three factors’ activities between PTE patients’ group and high-risk-factor patients’ group(P>0.05). Caprini Score of the two groups were both significantly higher than control subjects(P<0.01),but there were no significant differences between PTE patients’ group and high-risk-factor patients’ group(P>0.05).The two group induced thrombosis risk were higher than control group.Logistic regression analysis indicated that PS(P<0.05,the value of OR was 0.975) and AT-Ⅲ(P<0.05,the value of OR was 0.895) have a greater influence on the formation of PTE. Conclusion:The findings showed that the activity of PC,PS and AT-III may decreased with PTE and high condense status in pre PTE.The induced thrombosis risk in PTE is higher than healthy people with the lower activity of PC,PS,and AT-III.The level of anticoagulant factor activity decreased may represent high probability for thrombotic diseases.In the three anticoagulant factor,the PS and AT- III were implicated with PTE in this study.