Study On The Defects Of Anticoagulation Protein Deficiencies And Thrombosis In The Chinese Population Of The Susceptible To Thrombosis

Objective:To acquire the activity level of Protein C, Protein S and antithrombin of a group of Chinese patients with venous thromboembolism and a group of patients with cerebral infartion. To analyse the correlation between venous thrombosis formation and the activity level of Protein C, Protein S and antithrombin. To analyse the factors of thrombophilia among Chinese patients with venous thromboembolism.Methods:Collect 168 patients of venous thromboembolism and cerebral infarction who came to Liberation Army General Hospital for treatment from January,2014 to January,2015. Analyse the distribution of age and thrombus formation site.Collect 50 healthy physical examination personnel as the control group.Acquire the level of activity of PC, PS and antithrombin of patients and the healthy control.Results:Venous thrombosis and cerebral infarction occurs most at the age of 40s. Lower extremity vein is most likely to be affected in patients with venous thromboembolism with no age distribution differences, accounting for more than half all. Compared with the healthy control group, the difference of the three kinds of anti coagulation proteins in the patients with venous thromboembolism was statistically significant, and the P value was<0.01. Compared with the healthy control group, patients with cerebral infarction group have a lower activity level of PS and PC, with P value< 0.05, while the activety level of antithrombin shows no statistical significance, with P value> 0.05. Three types of anticoagulant proteins had no statistical significance, with P value> 0.05 between patients with Venous thromboembolism and patients with cerebral infarctionConclusion:As anticoagulant proteins ATS, PS, and PC are the susceptible factors of venous thromboembolism. PS, PC are the susceptible factors of cerebral infarction. Detection of anticoagulant protein has been more and more accepted and taken highly of by the majority of clinicians, the level of activity of anticoagulant proteins can provide a strong basis for the timely and reliable for the prevention and diagnosis of thrombotic diseases.Objective:Discuss detection AT:A and AT:Ag, PS, PC, D-dimer coagulation indexes such as the the clinical value of diagnosis of hereditary antithrombin deficiency.Methods:Choice of 42 patients with antithrombin deficiency as disease group, according to the PS, PC level will be further divided into disease group:simply AT lack of a group, AT joint PS lack of a group, AT joint PC lack of a group and all the lack of a group of AT, PS, PC. Choose 60 cases of healthy physical examination person as healthy controls. Two groups of patients with synthetic chromogenic substrate method test plasma antithrombin activity (AT:A) and plasma protein C (PC), protein S (PS) activity, with immune turbidimetric method test plasma antithrombin antigen (AT:Ag) and the concentration of plasma D-dimer. Using independent-samplesT test to compare the differences between the groups.Results:AT defects group of patients AT:A and AT:Ag level is significantly reduced, compared with healthy control group difference was statistically significant (AT:A t=-11.68, P<0.01; AT:Ag t=-6.118, P<0.01); the patient’s level of PS, PC reduce obviously in lack of AT joint PS, PC group, compared with healthy control group difference was statistically significant (PS t=-9.397,P<0.01; PC t=-3.065,P<0.01); AT defects patients plasma D-dimer level significantly increased, compared with healthy control group difference was statistically significant (t=4.358, P<0.01).Conclusion:Antithrombin deficiency is the main genetic risk factor for venous thromboembolism disease, detecting the blood coagulation associated indicators help in the early diagnosis of diseases, basis for clinical diagnosis and treatment, to prevent the occurrence of VTE has played a warning role.