The Correlational Research On VitB₁₂, Folic Acid And Homocystine Levels Of Vascular Cognitive Impairment

Objective(1)To study the difference between vascular cognitive impairment(VCI) and cerebral infarction with Vit B12, folic acid and homocystine levels;(2)To study the correlation between the severity of cognitive impairment and Vit B12, folic acid and homocystine levels;(3)To study the intervention in patients with different severity of vascular cognitive impairment.Methods 30 VCI and 30 cerebral infarction patients have been chosen respectively in our hospital’s outpatient and inpatient patients from November 2013 to December 2014, two groups were detected in plasma Hcy,Vit B12 and folic levels. Patients with VCI according to MMSE scores could divided into mild, moderate and severe groups.With Vit B12 and folic acid intervention on VCI patients four weeks.At the end of treatment retest plasma Hcy levels and MMSE scores.Results(1)Patients with VCI, compared with non-demented patients with cerebral infarction the blood Hcy levels were significantly increased(P <0.05), and Vit B12,folate levels were significantly decreased(P <0.05);(2)In VCI patients,the Hcy levels and MMSE scores were negatively correlated(P <0.05), the Vit B12,folate levels and MMSE scores were not significantly correlated(P >0.05);(3) After intervention the plasma Hcy levels in each VCI groups were statistically significant(P <0.05),the MMSE scores in mild and moderate VCI groups were statistically significant(P <0.05),but the MMSE socres of the severe group have no difference with before(P >0.05).Conclusion High Hcy levels are closely related to the development of VCI, short-term intervention with Vit B12 and folic acid can improve cognitive function in patients with mild and moderate VCI groups, the timely intervention with Vit B12 and folic acid can improve cognitive function with a certain extent, slow disease progression.