| Purpose: There is likely a relationgship between stormal cell-drived factor 1(SDF-1) /CXCR4 axis and prostate cancer metastasis. But it still lacked of definitive conclusions. The relationship between chemokine receptor CXCR4 expression and prostate cancer metastasis is going to be clarified with Meta analysis through this study. It might provide a new diagnostic method and a treatment way for the patients with prostate cancer metastasis.Methods: To collect the relevant literatures at home and abroad about the CXCR4 expression detected by immunochemistry. The relationship between CXCR4 expression and Gleason’s scores(≥7), T stage(≥T3), metastasis of prostate cancer, respectively, was explored with Meta analysis. Both including and exclusion criteria were layed down according to the systemic evaluation requirement. Intake criteria: 1. Literature type consisted of both case contrast research and formation research. Language type is comprised of Chinese and English.Researches were divided into 3 groups:(1) experiment group: the relationship between CXCR4 expression and prostate cancer metastasis;(2) control groups: ① the relationship between CXCR4 expression and prostate cancer Gleason’s scores(≥7); ② the relationship between CXCR4 expression and prostate cancer T stage(≥T3). 3.Intake conditions:(1) the intake literatures are about the relationship between CXCR4 expression and prostate cancer metastasis;(2) CXCR4 expression was detected by immunochemistry;(3) the number of people must be offered.either in experiment and contrast groups, or in positive high and low expression groups.Exclusion criteria:(1) data infirmity, effective data could not be obtained for research;(2)repeated literature research;(3) researchs with irrational design;(4) research without main observative indicators;(5) literatures of case reports, reviews, Meta analysis. Judging criteria:CXCR4 positive expression was detected by immunochemistry, scores were noted according to both degree of dyeing and average number of positive cells in each field, no coloring was 0, light yellow was 1, claybank was 2, brown was 3. Number of positive cells in each field<5% was 0,5%~25% was 1, 26%~50% was 2, 51%~75% was 3, >75% was 4. Total score of both degree of dyeing and average number of positive cells in each field <2 indicated negative, 2~3 indicated weak positive, 4~5 indicated positive, 6~7 indicated strong positive. Negative and weak positive was named lower expression, positive and strong positive was called higher expression.Literatures were widely and in detail screened according to the planned criteria. The screened literatures underwent quality evaluation and data extracted. Data were dealed with and analized by Revman4.2 software. Odds ratio(OR) and effective variant of intake literatures were used for Meta analysis.Results:Six of total 187 related literatures met the demands of Meta analysis. The result of tests for heterogeneity was displayed no heterogeneity existed between research groups. The fixed effect model combined with OR was used, the results displayed that there was no obvious relationship between CXCR4 expression and Gleason’s score(≥7). the OR was 1.59(95%confidence interal CI: 0.79 ～ 3.17; P = 0.19). In addition, there was no obvious relationship between CXCR4 expression and T stage(≥T3), the OR was 1.80(95% CI:0.76～4.30, P = 0.18).However, there was a positive relationship between CXCR4 strong positive expression and prostate cancer metastasis, the OR was 8.53(95% CI: 3.25~22.41, P<0.001).Conclusions:There is a positive relationship between CXCR4 strong positive expression and prostate cancer metastasis. There is no obvious relationship either between CXCR4 expression and Gleason’s score(≥7), or between CXCR4 expression and T stage(≥T3) by Meta analysis,... |
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