A Comparison Of The Effect Of Propofol Versus Sevoflurane On Blood Coagulation Functions Of Patients Undergoing Retorperitoneal Laparoscopy

Objective:To observe the changes of patients’ coagulation who undergoing retorperitoneal laparoscopy.By comparing the changes of the thromboxane B2(TXB2), endothelin-1(ET-1)and D-dimer in serum, and changes of prothrombin time(PT)and activated partial thromboplastin time(APTT).To investigate the effect of propofol and sevoflurane on blood coagulation functions of patients undergoing retorperitoneal laparoscopy. Methods:Sixty patients were randomly divided into 2 groups(n=30 each): propofol group(group P)and sevoflurane group(group S). Detection index:(1)Detection time: After induction of anesthesia( T1),after pneumoperitoneum 30min( T2),After pneumoperitoneum 60min(T3), after pneumoperitoneum 90min(T4).(2)coagulation indicators: To detect thromboxane B2(TXB2), endothelin-1(ET-1), D-dimer, prothrombin time(PT)and activated partial thromboplastin time(APTT)at each time point. Results:Coagulation index:In both groups, the plasma TXB2,ET-1 and D-dimer concentrations were higher after pneumoperitoneum(P<0.05);In two groups, PT after pneumoperitoneum 90 min(T4)when compared with those before pneumoperitoneum(T1)is shorter obviously(P<0.05), APTT had no obvious change(P>0.05). Compared with group S, In group P, the plasma TXB2, ET-1 and D-dimer concentrations were higher in surgery(P<0.05);In two groups, PT and APTT had no significant difference(P>0.05). Conclusion:For patients who undergoing retorperitoneal laparoscopy, the plasma TXB2,ET-1 and D-dimer concentrations were higher after pneumoperitoneum(P<0.05), sevoflurane can more effectively inhibit the body to release them than propofol, it may delay the formation of the hypercoagulable state.