Study On The Effect Of G-CSF、VEGF Changes In Patients With Acute Myocardial Infarction On Cardiac Function In Patients After PCI

Objective:Study of acute ST segment elevation myocardial infarction(STEMI) patients after percutaneous coronary intervention(PCI) of peripheral blood granulocyte colony stimulating factor(G-CSF), vascular endothelial growth factor(VEGF) and the relationship between the changes of cardiac function indexes. Methods:Due to acute myocardial infarction in patients undergoing emergency PCI44 cases, after the first 12 h, 24 h, 7 days collecting venous blood was measured in peripheral blood G-CSF, in patients with echocardiography VEGF levels and 3 months, according to patients3 months NYHA class, the better the patient group into cardiac function(NYHA> II level) and the control group(poor cardiac function, NYHA <II level). For VEGF and G-CSF and left ventricular ejection fraction(LVEF) correlation analysis. Results:After acute myocardial infarction window period(generally within 12 hours) after undergoing emergency PCI 12 h, heart function better group(NYHA≥II level) VEGF levels than the group with poor cardiac function(NYHA <II level),first 24 h, the heart function better group(NYHA≥II level) and poor heart function group(NYHA <II level) compared to significantly higher, on the 7th day, heart function better group(NYHA≥II level) was still significantly higher than the group with poor cardiac function(NYHA <II level),(P <0.05), peripheral blood VEGF levels were positively correlated with the LVEF. The heart function better group(NYHA≥II grade) G-CSF levels in relatively poor heart function after 12h(NYHA <II level) higher than the poor heart function(NYHA <II level),(P <0.05), on the 7th day, heart function better group(NYHA≥II level) was still significantly higher than the group with poor cardiac function( NYHA <II level),(P <0.05), peripheral blood G-CSF levels were positively correlated with the LVEF. In the study further found that(poor cardiac function, NYHA <II level) even in the control group, there are also G-CSF, VEGF levels and heart function LVEF levels were positively correlated. Conclusions:After acute myocardial infarction in patients with emergency PCI, peripheral blood VEGF and G-CSF significantly increased and sustained at a higher level, their heart function better. VEGF increased with the coronary collateral circulation and to establish an effective angiogenesis in ischemic myocardium. G-CSF may be associated with increased ischemic myocardium, damaged blood vessels, coronary plaque inflammation-induced bone marrow fibroblast cells and macrophages to produce relevant, bone marrow-derived endothelial progenitor cells(endothelial progenitor cells, EPCs) induction and migration damage to blood vessels, myocardial necrosis at the myocardial cells and by promoting endothelial cell regeneration and so on, thereby improving cardiac function.