| Objective:To analyze risk factors of morning blood pressure surge phenomenon and invest igate the possible mechanisms of this phenomenon.Methods:A total number of 192 patients with primary hypertension were chosen in the first affiliated hospital of Shanxi Medical University from 2014 March to 2014 Octo ber, all patients would undergo 24-hour ambulatory blood pressure measurement(A BPM).To calculate the level of morning blood pressure surge. According to whether the morning blood pressure level was more than 35 mm Hg, all the patients were div ided into two groups, the morning blood pressure surge group whose morning blood pressure level was more than 35 mm Hg and non-morning blood pressure surge group whose morning blood pressure level was less than 35 mm Hg.The general data of bot h groups’ patients were recorded respectively in age and sex. To detect all the pati ents’ total blood cholesterol(TC), triglyceride(TG), low density lipoprotein-cholestero l(LDL-C), high density lipoprotein-cholesterol(HDL-C), homocysteine(HCY), fasting blood glucose(BS) levels and record the smoking history of both groups.Analyze th e acquired data with the SPSS software and compare the two groups’ data and dra w the conclusion.Results:The level of blood total cholesterol(5.00±0.88mmol/L), low density lipoprotein-c holesterol(2.76±0.77mmol/L), homocysteine(31.12±31.10umol/L) of morning blood pr essure surge group is higher than the level of non-morning blood pressure surge grou p(respectively 4.51±1.07mmol/L,2.54±0.84mmol/L, 22.46 ±20.87umol/L), the difference between the two groups was significant(the P values were 0.010, 0.030, 0.041, P <0.05). And there is no significant difference between the two groups’ patients’ ag e(64.05 ±17.17 s, 58.35 ±14.68s), age structure(23 cases over 60 years old in the morning blood pressure surge group and 15 cases of less than 60 years; 80 cases ov er 60 years old in the non-morning blood pressure surge group and 74 cases of les s than 60 years),gender(16 male and 22 female cases in the morning blood pressur e surge group; 94 male and 60 female cases in the non-morning blood pressure surg e group), smoking history(16 cases with smoking history and 22 cases without smok ing history in the morning blood pressure surge group,89 cases with smoking histor y and 65 cases without smoking history in the non-morning blood pressure surge g roup) and the level of serum triglyceride(1.84 ±1.37, 1.74±1.08mmol/L), high density lipoprotein-cholesterol(1.37 ±0.40, 1.22±0.28mmol/L), fasting blood glucose(5.63 ±1.55, 6.02±4.81mmol/L)(P = 0.065, 0.121, 0.064, 0.604, 0.146, 0.610, P > 0.05). It is still not sure that there is a difference between the morning blood pressure surge grou ps’ age, sex, smoking history and blood triglyceride, high density fat cholesterol, fa sting blood glucose with the non-morning blood pressure surge group.Conclusion:(1).The patients’ level of blood total cholesterol, low density lipoprotein cholest erol, homocysteine in the morning blood pressure surge group is higher than non-m orning blood pressure surge group, and the difference is significant.(2). Elevation of serum total cholesterol, low density-lipoprotein cholesterol, hom ocysteine level is a risk factor of morning blood pressure surge phenomenon.(3).There is no significant difference between the level of fasting blood glucose,triglyceride, high density fat cholesterol, smoking history with the patients in the morning blood pressure surge group and the non-morning blood pressure surge.(4). The relationship between the elderly, gender and blood pressure surge phe nomenon is still needed to be confirmed. |
