Clinical Value Of Procalcitonin, C-Reactive Protein And Erythrocyte In The Diagnosis Periprosthesic Infection Before Hip Or Knee Revision

OBJECTIVETo investigate the value of procalcitonin,C-reactive protein and erythrocyte sedimentation rate alone and their combination in diagnosis of periprosthetic infection.METHODSSixty-two patients suffering hip or knee revision were recruited in our surgery team from Jan 2010 to Dec 2014. According to final revision reason, the patients were grouped into the periprosthetic infection group and aseptic loosening group. PCT, CRP and ESR were detected before the revision surgery. The results of the above detections were used as criteria to diagnose periprotheic infection or not. When any two results of the above examinations were positive, the patient was diagnosed with periprosthetic infection. When any two results was negative, the patient was diagnosed with aseptic loosening. The diagnostic results were compared with the "diagnostic criteria".RESULTSThe sensitivity, specificity and accuracy of PCT, CRP, ESR and combination of three methods in distinguishing periprosthetic infection from aseptic lossening were 47.1%,100% and 71.0%,85.3%,89.3% and 87.1%,76.5%,85.7% and 80.6%,97.1%,92.9% and 95.2%,respectively.CONCLUSIONDetection of PCT has low sensitivity in the diagnosis of periprosthetic infection, but has excellent specificity. Comparing with PCT, CRP or ESR has higher sensitivity and lower specificity in the diagnosis of periprosthetic infection. Combined PCT,CRP and ESR can significantly improve the diagnosis of periprosthetic infection.