Changes Of The Adaptive Immunity In ITP During Pregnancy

Objective:To reveal changes of the adaptive immunity in ITP during pregnancy and its clinical significance by detecting the lymphocytes and their subsets. Methods:With instrument method to test the blood routine& FCM to lymphocyte subsets. The white blood cell and lymphocyte count were associated with innate and adaptive immunity respectively. Results:The white blood cell and granulocyte cell count and their percentage increased significantly in ITP during pregnancy(P<0.05), whereas the lymphocyte percentage decreased significantly(P<0.05) (the lymphocyte count showed no significant change(P>0.05)); As for the lymphocyte subsets in ITP during pregnancy, the CD3+cell and CD4+cell count increased significantly(P<0.05), the CD19+cell and NK cell count decreased significantly(P<0.05), while no significant change was found in CD8+cell count and CD4+/CD8+(P>0.05). Conclusion:The innate immunity is enhanced, whereas the adaptive immunity is weakened in ITP during pregnancy. The cell-mediated immunity became more active, while the humoral immunity was restrained in ITP patients during pregnancy. This also supported the treatment of ITP during pregnancy with small dose of glucocorticoid.