The Analysis Of Correlative Factors Of In-stent Restenosis After Subclavian Artery Stent Implantation

Objective:To evaluate the rate of in-stent restenosis and to analyze the influencing factors of in-stent restenosis after subclavian artery stent implantation, using caroyid artery color Doppler ultrasound(CDUS) as the reference standard to diagnose extracranial artery stenosis or occlusion. Methods:The present study selected 67 patients from the First Hospital of Jilin University, which were diagnosed with stenosis or occlusion of the subclavian artery by CDUS and underwent the subclavian artery stent implantation surgery successfully through Digital Subtract Angiography(DSA) confirmed during February 2012 to December 2015. 35 Patients had complete clinical data, which were included in this study. There were 26 males and 9 females in the age of 42-76 and the average age were 59.60±7.62. According to the results of the countercheck, the patients were divided into ISR group of 11 cases with 7 males and 4 females and non-ISR group of 24 cases with 19 males and 5 females. Stent length, stent diameter, peak systolic velocity(PSV) and spectrum were recorded and the results of two groups of detection were compared and analyzed, and the rate of in-stent restenosis were evaluated. This study collected their clinical data, biochemical indicators and the related data of operation in order to analyze the influencing factors of in-stent restenosis by single factor analysis. Results:35 patients were detected 37 stenosis or occlusion of the subclavian artery. There were 11 patients with the in-stent restenosis, which was in the incidence of 31.4%(11/35). Single factor analysis showed that:(1) ISR group and non-ISR group statistically differed in smoking, diabetes and homocysteine levels(P<0.05). But there was no statistical difference(P>0.05) in age, gender, history of hypertension, hyperlipidemia, heart disease, triglycerides, low-density lipoprotein, high-density lipoprotein and fibrinogen.(2) Two groups statistically differed in stent length(33.61±6.40 vs 27.73±7.21 P<0.05). But there was no difference in stent diameter, the number of stent implantation, extent of presurgical stenosis(P>0.05). Conclusions:The rate of in-stent restenosis after subclavian artery stent implantation is approximately 31.4%. Smoking, diabetes, stent length and homocysteine levels are correlated with in-stent restenosis, which can be as the predictors.