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Efficacy And Safety Of Oral Branched-Chain Amino Acid Supplementation In Patients Undergoing Interventions For Hepatocellular Carcinoma:a Meta-Analysis

Posted on:2016-02-06Degree:MasterType:Thesis
Country:ChinaCandidate:Y Q ChenFull Text:PDF
GTID:2284330482953652Subject:Internal Medicine
Abstract/Summary:PDF Full Text Request
Most hepatocellular carcinoma (HCC) patients have complications including cirrhosis and malnutrition. The efficacy of supplementation with oral branched-chain amino acids (BCAAs) in HCC patients undergoing interventions is still not confirmed. The pooled risk ratio (RR) and standardized mean difference (SMD) were used to assess the supplementation effects. A total of 11 eligible studies (974 patients in total) were searched and included in our analysis. Oral BCAA supplementation helped to maintain liver reserve with higher serum albumin (SMD=0.234, 95% CI:0.033-0.435, P=0.022), and lower rates of ascites (RR=0.545,95% CI:0.316-0.938, P=0.029) and edema (RR=0.494,95% CI:0.257-0.952, P=0.035) than in the control group. BCAA supplementation seemed to be effective in improving 3-year mortality, but the efficacy was not confirmed. Apparent effects were not found in improving HCC recurrence, total bilirubin, ALT, or AST. BCAA supplementation was relatively safe without serious adverse events for HCC patients. BCAA supplementation may be clinically applied in improving liver reserve for HCC patients and furtherly improving the quality of life.
Keywords/Search Tags:Branched-chain amino acids, Hepatocellular Carcinoma, Meta-analysis
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