Portable Noninvasive Blood Glucose Detection By Optical Fiber Surface Plasmon Resonance

In recent years, as people living standard rise, the diabetes patients also increased.In order to effectively control and prevent the progression of diabetes,how to real-time field,fast and convenient to test the blood sugar levels become the focus of the attention.The purpose of this paper is to use optical fiber surface plasmon resonance (SPR) technology for detecting glucose levels conveniently in saliva, and then reflecting the blood sugar condition.The glucose concentration of human saliva is closely related to that of human blood. The noninvasive blood glucose monitoring can be realized by measuring the glucose concentration of saliva. Considering the complexity of the interstitial fluid, the Glucose Oxidase (GOD) which can specifically absorb glucose molecules can be used to modify the optical fiber surface plasmon resonance (SPR) sensor to realize glucose selective measurement. At the same time, to the portability of the blood sugar detector and the conveniency of the probe replacement, a kind of tip type probe based on a miniature integrated optical fiber SPR sensor was set up, and the resolution ratio of this system to the low concentration of glucose was discussed. The experiment results show that this sensor can be used to detect the glucose concentration of saliva in order to response blood glucose levels, which provides an efficient scheme for the exploitation of portable noninvasive blood glucose detector.