Platelet Indices In Patients With Pulmonary Arterial Hypertension

Objective: Pulmonary arterial hypertension(PAH) is a chronic progressive disease characterized by persistent elevation of pulmonary artery pressure. Vasoconstriction,remodeling, and thrombosis cause increased pulmonary vascular resistance and pressure.Previous studies have demonstrated that platelet activation occurs in patients with PAH.Our aim was to assess the mean platelet volume(MPV), an indicator of platelet activation in patients with PAH. Methods: The study group consisted of 352 patients with PAH. An age-, gender-, and body mass index– matched control group was composed of 400 healthy volunteers. All patients underwent physical examination, echocardiography, and diagnostic cardiac catheterization. We measured serum MPV values and platelet counts in patients with PAH and control participant. Results:(1)MPV was significantly higher among the patients with PAH when compared with control group(8.68+0.87 vs 8.02±0.68 fl, respectively; P = 006).( 2) In univariate and multivariate logistic regression analysis, RV diameter(OR=1.101,95%CI 1.026 to 1.181,P=0.008) and RA diameter(OR=1.064,95%CI 1.013 to 1.118,P=0.013) were independent predictors of PAH-CHD.Conclusion: We have shown that MPV was elevated in patients with PAH,Our study demonstrated that RV diameter and RA diameter were significantly associated with PAH-CHD.