The Study On Bone Mineral Density And The Concentrations Of Serum 25-hydroxyvitamin D In The Parkinson’s Disease Patients

Objective:This study analyses the bone mineral density and serum concentration of 25-hydroxyvitamin D on Parkinson’s Disease(PD)patients, trying to find the ratio of fracture on patients with PD. Method:We collected the data of PD patients and the healthy, both PD patients and the healthy were measured the bone mineral density by the Dual-energy X-ray absorptiometry detector, and use the enzyme-linked immunos-orbent to detect the concentration of 25-hydroxyvitamin D in serum. We used the UPDRS scores and Hoehn-Yahr scores to evaluate the condition of the PD patients, the PD patients were divided into some groups based on the scores. Result:In this study, the mean of the neck of femur T score of the PD group is-1.88±0.85, while the control group is-1.36±0.94, the PD group have a significantly decrease compared with the control group(P<0.01). The mean of the lumbar total T score of the PD group is-1.86±1.06, while the control group is-1.21±1.31, the PD group have a significant-1y decrease compared with the control group(P<0.01).The mean of the concentration of the 25-hydroxyvitamin D in PD group is 38.97±14.95nmol/L and the control group is 49.08±15.68nmol/L, the PD group have a significantly decrease compared with the control group(P<0.01). The neck of femur T score of PD have a negative correlation with the HY grades, but no significant correlation(Spearman P=0.277). Also, we did not find the significant correlation(Spearman P=0.742) between the lumbar total T score of PD and the PD Hoehn-Yahr grades. We didn’t find the significant correlation (Spearman P:0.913,0.541)between the neck of femur T score and the lumbar total T score of PD patients with the UPDRS scores of PD patients. No significant correlation(P=0.147) between the concentration of the serum 25-hydroxyvitamin D of PD and the PD Hoehn-Yahr grades, although the CI is-0.215. The similar result was found between the serum 25-hydroxyvitamin D with UPDRS scores of PD patients(Spearman P:0.069). Conclusion:The bone density of PD group is lower than the control group and the serum concentrations of 25-hydroxyvitamin D is lower than the control group. This two factors may have result to the higher risk of the fracture on the PD patients.