Relationship Between Neutrophil-lymphocyte Ratio And Glycated Hemoglobin A1c In Patients With Type 2 Diabetes Mellitus

Background and Objective:Type 2 diabetes mellitus is one important part of metabolic syndrome,which harms people’s health seriously. The pathogenesis of type 2 diabetes mellitus is very complex. The correlation between diabetes and inflammation has been widely recognized in recent years. Lots of studies have shown that diabetes mellitus is a kind of chronic low-grade inflammation. Neutrophil-lymphocyte ratio is an important inflammatory marker, which has been much more studyed in recent years. It’s reported that it’s closely related with diabetes and other metabolic diseases. With the NLR rising, the risk of insulin resistance and diabetes complications increased. Considering a variety of associations with diabetes, it may also be related to the potential long-term prognosis in patients with diabetes. NLR has unique advantages. It cost less, and the test is more stable. It also more comprehensively reflect the state of the immune response, with higher clinical value. This article aims to explore the association between neutrophil-lymphocyte ratio and the level of hemoglobin type A1 c in type 2 diabetes mellitus, providing more help for clinical treatment of diabetes. Research Methods:292 type 2 diabetes mellitus patients in China-Japan union hospital of jilin university were collected, which were in line with the 1999 WHO diagnostic criteria for diabetes, including 147 males,145 females. We collected the patient’s clinical datas, including age, sex, duration,height, weight, blood pressure; and biochemical indicators, including blood routine examination, glycated hemoglobin, triglycerides, low-density lipoprotein. We divided them into two groups according to the level of glycated hemoglobin A1c:less than or equal to 7%(group 1, n = 68), more than 7%(group 2, n = 224); calculating the NLR, analyzing the difference between the two groups. Research Results :1.Compared with group 2, the duration, sex ratio, systolic blood pressure, diastolic blood pressure, triglycerides, low-density lipoproteins, body mass index(BMI), platelets in group1 had no significant differences(P> 0.05).2.The NLR, leukocyte and neutrophil count in group 2 were significantly higher than that in group 1(P<0.05),but the lymphocyte count was significantly lower than that in group 1(P<0.05).3. Hb A1 c level was positively correlated with FPG and NLR.(r=0.758,0.617,P<0.01). Regression analysis showed that FPG、NLR may be risk factors of Hb A1 c. Conclusions:1.There may be a significant relationship between NLR and blood glucose regulation.2. Increased NLR level is associated with elevated Hb A1 c in patients with type 2 diabetes mellitus, which is the influence factor of Hb A1 c.