Risk Factors And Chinese Ischemic Strock Subclassification In Cerebral Infraction In Young Adults

Objective:To investigate the risk factors,characteristics of CISS classification and relationships between risk factors and CISS of cerebral infraction in young adults.Methods:There were 80 hospitalized young adults with cerebral infraction.these patients were enrolled in young patient group while 80 volunteers as a control group,the ratio of male to female ratio and age matched with the young patient group and 100 older age patients with cerebral infraction as a middle-aged and old patient group.The clinical data of all the subjects were collected.The risk factors,characteristics of CISS typing and relationships between risk factors and CISS of cerebral infraction in young adults were analyzed retrospectively.Results:(1)Comparison of related factors between the young patient group and control group,young patient group smoking(P=0.016),Drinking(P=0.024),hypertension(P=0.001),diabetes(P=0.001),hyperlipidemia(P=0.004),hyperhomocysteine mia(P=0.020),carotid atherosclerosis(P=0.000)was significantly higher than in the control group except heart disease(P=0.064).Logistic regression analysis showed,those eight related factors are independent risk factors for young patient group.(2)In young patient group,incidence of men more than woman.comparison of related factors between the young patient group and middle-aged and old patient group,young patient group smoking,drinking was significantly higher than in the middle-aged and old patient group,and this more noticeable in young male patient.young patient group hypertension,diabetes,heart disease,carotid atherosclerosis was significantly lower than in the middle-aged and old patient group and hyperlipidemia,hyperhomocysteinemia was no significant difference.(3) The CISS classification in young patient group was as follows:LAA42.5%,PAD27.5%,UE17.5%,OE7.5%,CS5.0%.The proportion of male patients in LAA was significantly higher than that of female(P<0.05).The young patient group UE etiology classification was obviously higher than middle-aged and old patient group,and LAA etiology classification was significantly lower than middle-aged and old patient group.(4)The analysis of relationships between risk factors and CISS of young patient group shows that,male(P=0.02,OR1.107),smoking(P=0.038,OR2.605),Hyper Ten sion(P=0.032,OR2.718),Hcy(P=0.037,OR3.039),carotidatherosclerosis(P=0.017,OR3.729)were correlation with LAA. Diabetes(P=0.016,OR3.561),carotid atherosclerosis(P=0.017, OR5.567)were correlation with PAD.heart disease(P=0.000,OR2.333)were correlation with CS.Conclusion:1.Smoking,drinking,hypertension,diabetes,heartdisease,Hyperlipide mia,hyperhomocysteinemia,carotid atherosclerosis are independent risk factors for young patient group.2.Young patients with cerebral infraction were significantly affected by unhealthy living habits(smoking,drinking) more significant in young male patient.3.The CISS classification in young patient group was as follows:LAA,PAD,UE,OE,CS.There were differences between the young patient group and the middle-aged and old patient group on the characteristics of CISS classification.There were also differences between different genders in young patient group.4.The occurrence of different CISS subtypes were related to different risk factors.