Research Of Risk Factors Of IVIG Non-responsiveness With Kawasaki Disease

Objective:ComparIing the clinical characters and laboratory features of complete KD with incomplete KD to analyze the high risk factors of IVIG non-responsiveness with Kawasaki disease.Methods:Retrospective reviews of medical records from the The First Affiliated Hospital of Xinjiang Medical University were done to identify KD inpatient cases from December,2004 to December,2014. The data were analyzed by SPSS 18.0 software with X2 test. Measurement data were calculated by t test. The high risk factors of IVIG non-responsiveness in KD were investigated. multivariate logistic regression analysis were performed to explore the high risk factors for IVIG non-responsiveness.A value of P <0.05 was considered statistically significant. Results: 1)The difference of Cervical lymph node enlargement between IVIG non-responsiveness and IVIG responsiveness with Complete Kawasaki disease was highly statistically significant(P <0.05). The difference of Percentage of Neutrophil between IVIG non-responsiveness and IVIG responsiveness with Incomplete Kawasaki disease was highly statistically significant(P <0.05). The difference of White Blood Cell and Percentage of Neutrophi and Aspartate aminotransferase and sodium between IVIG non-responsiveness and IVIG responsiveness with Complete Kawasaki disease was highly statistically significant(P <0.05).2)Cervical lymph node enlargement and Percentage of Neutrophil were positively correlated with IVIG non-responsiveness but negatively correlated with sodium in the Complete Kawasaki disease.Conclusions: In Icomplete Kawasaki disease, the Percentage of Neutrophil can be used as a prediction index of IVIG non-responsiveness. In Complete Kawasaki disease, Cervical lymph node enlargement and Percentage of Neutrophil increasing and sodium reducing were highly risk factors.