The Effects Of Ginkgolide B On The Cognitive Function Of Rats Exposed To Hypoxia High Altitude

Objective:To study the effects of cognitive function in acute hypoxia rat model,and evaluating the effects of GB on this model.Methods:Make a use of hypobaric chamber to simulate acute high altitude, Morris water maze was applied to evaluate 8000m and 8500m for 24h and 6000m for 7d groups outside,and 6000m for 24h and 7d groups inside.Then confirm the condition and assessment of the acute hypoxia rat model.On the basis of this model, administration of GB was used to evaluate the cognitive function of rats.Results:1、 The time staying in target quadrant under altitude of 8000m、 8500m for 24h and 6000m for 7d outside the hypobaric chamber has no difference with normoxia group.Combine the pathology the same term, reoxygenation can effects the true results of morris water maze.2＞The time staying in target quadrant of 6000m for 24h group has no difference with normoxia.As time going on,the time staying in target quadrant of the rats exposed to 6000m for 4d was decreased(P<0.05). Exposed to 6000m hypoxia condition for 4d in high altitude for 4d may significantly influence the learning and memory of rats.3＞Administration of 1Omg/kg.d GB can improve the cognition function of the rats exposed to 6000m high altitude.Conclusion:1、The intervention of reoxygenation can effect the results of Morris water maze assessment outside the hypobaric chamber.Reoxygenation also can ameliorate the memory impairment induced by acute hypoxia.2、The model that rats exposed to 6000m high altitude for 4d，evaluating inside the hypobaric champer can achieve the real and reliable results.3、Administration of GB can improve the cognition function of rats by adjusting the internal environment,and the consequence has no diference with reoxygenation interference.