| Objective:To understand the abnormal levels and distribution of lipoprotein(a),and analyze the relationship between lipoprotein(a) and other lipid components; To investigate the correlation of statins intake patients’ lipoprotein(a) with the severity of atherosclerosis, the factors of atherosclerosis, and the related influence factors.Methods:1. A study was performed on a total of 11946 cases of which the patients took detection of blood lipid all items in Navy General Hospital between January 2015 and December 2015, including 6146 cases of male, female 5800 cases. To analyse the abnormal levels and distribution of lipoprotein(a) According to the different gender and age group, and to investigate the relationship between LP(a) and other lipid components. 2. A study was performed on a total of 239 cases of which the patients took regular statins in more than 3 month between December 2014 and July 2015 in navy general hospital, including 97 cases of male, female 142 cases.Their blood lipid all items, uric acid, high-sensitivity C-reactive protein and homocysteine levels were detected as well as their carotid intima-media thickness(Carotid intima-media thickness, CIMT) through arterial ultrasound measurement. The subjects were divided into LP(a) normal and abnormal groups based on LP(a) level 300mg/L as a cut-off point. The differences of lipid uric acid, high-sensitivity C-reactive protein, homocysteine and atherosclerosis between the two groups were analyzed comparatively;And to investigate the correlation of lipoprotein(a) with the factors of atherosclerosis and the related influence factors.Results:Statistical results of 11946 cases of blood lipid test:11946 cases of statistical objects, 2446 cases of abnormal LP(a), namely the LP(a) > 300 mg/L, accounted for about 20.48% of the statistical population. TC normal but LP(a) abnormal accounted for about 12.35%; LDL-C normal but abnormal LP(a) accounted for about 16.05%; TC and LDL-C normal but abnormal LP(a) accounted for about 12.29%; Normal TC but LDL-C and LP(a) abnormal for about 0.08%. Normal LDL-C but TC and LP(a) abnormal accounted for about 3.78%; TC, LDL-C and LP(a) are abnormal accounted for about 4.34%. The women’s average levels of LP(a)(241.03 ± 199.71 mg/L) were higher than men’s, there are statistically significant(P < 0.05). The differenceof lipopretion(a) between different age groups have statistical significance(P<0.05),as the level of LP(a) has a tendency to rise as the age increases. The total cholesterol(TC)(4.49±1.20 mg/L) and low density lipoprotein cholesterol(LDL-C)(2.72±0.86 mg/L) of LP(a) normal group’ were higher than LP(a) abnormal group’ TC(4.65 ± 1.11 mg/L) and LDL-C(2.72±0.86 mg/L);and the relationship between LP(a) with TC and LDL-C were positively related(r = 0.269 and 0.389, P < 0.05). Statistical results of 239 patients taking statins more than 3 month 239 cases of statins intake patients’ LP(a), UA, hs-CRP, Hcy and CIMT were respectively(340.63±274.50) mg/L,(308.92±81.47) umol/L,(2.02±2.05) mg/L,(13.02±5.12) umol/L,(1.18±0.20) mm. The CIMT(1.01±0.20mm) of LP(a) normal group was lower than LP(a) abnormal group’ CIMT(1.21±0.18mm), there are statistically significant(P < 0.05),But the TG(1.74±1.11mm),UA(318.82±84.01mm)of LP(a) normal group were higher than LP(a) abnormal group’ TG(1.41±0.68mm),UA(293.64±75.30mm), there are statistically significant(P < 0.05). BMI, waist circumference, hs-CRP, Hcy, total cholesterol, high-density lipoprotein cholesterol, low density lipoprotein cholesterol and apolipoprotein A1, apolipoprotein B between the two groups, there was no statistically significant difference. LP(a) and CIMT were positively correlated( r = 0.359, P = 0.000),and there were no correlation between LP(a) and UA,hs-CRP, Hcy. LP(a) levels between different sex, age, BMI, waist circumference, there was no smoking and there was no history of hypertension subgroups were not statistically significant difference, LP(a) and the above indicators also have no linear relationship. 239 cases of statins intake patients, 94 cases of abnormal LP(a), accounted for about 39.3% of the statistical population. 80 cases of TC normal but LP(a) abnormal, accounted for about 33.47%; 92 cases of LDL-C normal but abnormal LP(a) accounted for about 38.05%; 79 cases of TC and LDL-C normal but abnormal LP(a) accounted for about 33.05%.Conclusions: Abnormal levels of LP(a) is high, especially in the TC and LDL- C, respectively, and at the same time, under normal circumstances, It should be pay attention to the LP(a) level detection. After the Statin intervention LP(a)level is still high and was positively than with CIMT, predicting a more sever atherosclerosis, which may indicate the residual risk of LP(a) hardening of the arteries。 It need to seek further effective treatment measures to reduce LP(a). |
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