Expression Of Dendritic Cells In Hepatocellular Carcinoma And Any Association With Tumor Angiogenesis

Objective To explore the expression of the number and maturation of DCs in hepatocellular carcinoma(HCC) tissues and any association with tumor microvascular density( MVD). Methods Fifty cases of HCC tumor and paraca-rcinomatous tissues were collected.Immunohistochemistry methods was used to detect the expression of CD11 c,CD34,and major histocompatibility complex classⅡ(MHC-II)to analyze the correlation among them. Results CD11c、MVD in HCC tissues was(31.10±5.39、47.40±15.85) higher than that in the surrounding tissues(25.68±4.60、16.28±7.37)(P<0.01).The MHC-II inHCC tissues was significantly lower(13.34±3.99)than that in the surrounding tissues(18.92±5.09)(P<0.01). There was a negative correlation between the MVD value and the expression of MHC-II(r=-0.480 P<0.01); there was no correlation between the MVD and the expression of CD11 c.The expression of CD11 c and MHC-II in HCC tissues we-re related to HCC metastasis and TNM classification(P<0.05), But with the patient’s age, gender, tumor size, tumor capsule integrity, liver cirrhosis, Edmondson grade, AFP level and HBsAg and other clinical pathological characteristics were not related. The expression of MVD in hepatocellular carcinoma was related to the clinical pathological features of HCC metastasis, TNM stage, liver cirrhosis, Edmondson classification, AFP level,and so on(P<0.05), And the age, sex, HBsAg, tumor diameter, tumor capsule and other clinical pathological characteristics were not related. Conclusion In HCC tissues,The expression of CD11 c and MHC-II were relatedto HCC meta-stasis and TNM classification;The higher expression of MVD was a negative correlation with MHC-II,which indicate that the increase of maturation of DCs maybe come one of the potential targets anti-angiogenesis therapy of HCC.