| Background : Chronic obstructive pulmonary disease is an airway disease characterized by progressive airway obstruction. The morbidity and mortality of COPD continue to rise and will presumably continue to deteriorate in the coming decades. It’s a worldwide public health problem. Bronchiectasis is a respiratory disease, and the symptoms of which typically include a chronic cough with sputum production. Because of the rising morbidity of tuberclosis and drug resistance, the prevalence of bronchiectasis has reccently been increased, and it is now one of the three leading suppurative respiratory diseases. Traditionally, we thought that there were not so many connections between the two diseases. More and more observators have found that the two diseases could not only occur separately but also coexist in clinic. Bronchiectasis was defined as a comorbidity of COPD for the first time in the 2014 Global Initiative For chronic obstructive lung disease guidelines. In the 2015 Global Initiative for chronic obstructive lung disease guidelines, it was emphasized that bronchiectasis can influence the nature history of Chronic obstructive pulmonary diaseas.Purpose: to explore the declines in lung function in patients with bronchiectasis and to evaluate the application of bronchodilators for the treatment of bronchiectasis patients who have changes in lung function without a diagnosis of COPD; To detect the proportion of COPD in patients with bronchiectasis who had taken lung function test; to discuss the value of lung function testing for bronchiectasis patients, to analyze the risk factors of patients with bronchiectasis combined with COPD.Methods: This experiment analyze the medical records of patients who were in the jilin university affiliated hospitals with a diagnosis of bronchiectasis.The dates of the survey include sex, age, smoking history, time of clinical symptom remission, records of high-resolution computer tomography, indices of lung function, and the application of bronchodilators. To explore lung function changes in patients with bronchiectasis and clarify whether a patient with COPD or not at the same time referring to the Global Initiative For chronic obstructive lung disease guidelines. Using statistical methods(independent sample T test,chi-square test) to analyze the information collected above and clarifying whether it has a statistical significance.Results:(1)The 246 patients with bronchiectasis who had taken lung function test were included in our experiment. amongh them, 101 patients had changes in lung function without a diagnosis of COPD(41.7%). Chronic obstructive pulmonary disease was present in 134(58.9%).(2)The changes in lung function of patients with bronchiectasis who were not diagnosed as COPD: 26.7% with normal ventilation function. 17.8% with mild obstructive ventilatory disorder, 3.0% with mild restrictive ventilatory disorder, 26.7% with mild combined ventilation dysfunction, 12.9% with moderate combined ventilation dysfunction. 12.9% with severe combined ventilation dysfunction.(3)Among the 101 patients with bronchiectasis who had changes in lung function without a diagnose of CODP, 59 were administered with bronchodilators for the treatment. The time of clinical symptom remission was 2.8 ± 1.1 days. For the rest 42 patients without bronchodilators, the time of clinical symptom remission was 4.1±0.9days. The differences was significant(independent sample T test,P<0.05).(4) The exploration of risk factors: Smoking history: 72 of the 101 patients with bronchiectasis, who had changes in lung function without a diagnosis of CODP(71.3%),didn’t have smoking history. Forty six of the 145 patients with bronchiectasis combined with COPD had smoking history(38.6%). The differences was significant(chi-square test,P<0.05). Age: The age of 101 patients with bronchiectasis,who had changes in lung function without a diagnose of CODP,was 57.9±12.0 years. The age of 145 patients with bronchiectasis combined with COPD was 62.6±9.7years. The differences was significant(independent sample T test,P<0.05). Sex: among the 246 patients included in our experiment, 141 are female, 105 are male. Seventy-seven female patients with bronchiectasis were diagnosed as COPD(54.6%). Sixty eight male patients with bronchiectasis were diagnosed as COPD(64.8%). The differences was not significant(chi-square test,P>0.05).Conclusions:(1)There are mild to sever lung function changes in patients with bronchiectasis, and with the decline of lung function. Some patients with bronchiectasis can be diagnosed as COPD. It has significant meaning to carry out lung function test.(2)The application of bronchodilators for patients with bronchiectasis who had changes in lung function without a diagnose of COPD is beneficial in the treatment. It can relieve clinical symptoms.(3)Smoking history, advanced in years are found as the risk factors for patients with bronchiectasis combined with COPD. |
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