Study Of Resting-State Brain Functional Magnetic Resonance Imaging In Somatoform Pain Disorder

Part one:Study of mental health status and degree of pain of patients with somatoform pain disorderObjective:To explore the relationship between the anxiety and depression status and pain degree of patients with SPD.Materials and Methods:15 patients with SPD and 15 well matched(age, gender and education) healthy subjects were investigated in this study. HAMA scale and HAMD scale were performed in both healthy control group and SPD group to estimate the situation about anxiety and depression, and the degree of pain of patients with SPD was assessed by using the NRS scale. The differences of HAMD and HAMA scores between patients with SPD and normal controls were compared. The correlation between HAMA, HAMD scores and NRS scores of patients with SPD were analyzed.Results:1. Compared with the control group, the scores of HAMA and HAMD in patients with SPD were significantly increased (P<0.05).2. No significant correlations were observed by Pearson’s correlation analysis between the HAMA, HAMD scores and NRS scores of patients with SPD.Conclusions:1. The results of HAMA and HAMD in patients with SPD were significantly higher than those in normal controls, which indicated that patients with SPD had anxiety and depression disorders in different degree, and verified the phenomenon of the comorbidity of anxiety disorders, depressive disorders and SPD.2. There was no significant correlation between the severity of pain and anxiety and depression symptoms in SPD patients.Part two:Study of ReHo-based resting-state brain fMRI in patients with somatoform pain disorderObjective:To investigate regional activity abnormalities in resting brain of patients with SPD and the relationship between changed ReHo values and the degree of pain in patients with SPD in those abnormal brain regions.Materials and methods:A total of 15 patients with SPD and 15 healthy volunteers were enrolled in this study. Acquiring the resting-state data of patients with SPD after scoring the degree of pain. Pre-process rs-fMRI data and calculate the ReHo values of the whole brain of all subjects. After statistical analysis, the meaningful brain regions of patients with SPD were obtained. The correlation between the ReHo values and the NRS scores of patients with SPD was analyzed.Results:1. Compared with the control group, the patients with SPD showed an increase of ReHo value in right cerebellum posterior lobe, while the ReHo values in left superior temporal gyrus, left post-central gyrus, right cerebellum anterior lobe, right cerebellum culmen, and declive was decreased.2. The correlation analysis showed that there was no significant correlation between the changed ReHo values and NRS scores in above regions of patients with SPD (P>0.05).Conclusions:1. The patients with SPD showed an significant increase of ReHo value in right cerebellum posterior lobe, while the ReHo values in left superior temporal gyrus, left post-central gyrus, right cerebellum anterior lobe, right cerebellum culmen, and declive was significantly decreased, it’s suggested that SPD is linked with the abnormal activity of local neurons in these brain regions.2. There was no significant correlation between the changed ReHo values and the pain degree in the abnormal activated regions of patients with SPD.