Clinical Study On TCM Distribution And Related Risk Factors In Hypertensive Patients Of Morning Blood Pressure Surge

ObjectiveA clinical study to explore the distribution of TCM syndrome types of hypertensive patients with morning blood pressure surge and the correlation between the risk factors and morning blood pressure surge.MethodsAdopted patients diagnosed with hypertension in cardiovascular department of Guangdong TCM Hospital, carried 24h ambulatory blood pressure monitoring and screened out the patients with MBPS which next completed the rest examinations, after collecting clinical relevant data, used SPSS statistics software to analysis the distribution of TCM syndrome types on patients with MBPS and the correlation of the risk factors and MBPS, like age, blood pressure level, hypertension pathogenesis, blood lipids, urinary microalbumin, intima media thickness,24h blood pressure circadian rhythm, etc.Results110 patients were included. (1)Compared by TCM syndrome types, liver-fire excess type(26 cases,23.6%), average MBPS is 37.54±1.58mmHg;hyperactivity of yang due to yin deficiency type(18 cases,16.5%), average MBPS is 36.79 ±1.03mmHg; stagnation of phlegm-dampness type (43 cases,39.1%), average MBPS is 38.88±2.64mmHg; yin-yang deficiency type(23 cases,23.9%), average MBPS is 36.99±0.96mmHg. By analysis of variance, P＜0.05. (2)Compared by blood pressure level, MBPS has a rising tendency with the higher level (ANOVA, P<0.05).(3)By hypertension pathogenesis, MBPS has a rising tendency with longer pathogenesis (ANOVA, P<0.05). (4) By age groups, there’s no statistical significant difference (ANOVA, P>0.05). (5)By IMT, average MBPS of bilateral increased IMT＞average MBPS of unilateral increased IMT＞bilateral normal IMT(ANOVA, P＜0.05). (6)By 24h blood pressure circadian rhythm, there is no statistical significance between the 24h-BP circadian rhythm existed group and the abnormal 24hBP circadian rhythm group (t-test, P＞0.05). (7)By AASI, there’s no statistical significant difference(t-test, P＞0.05).(8)By the blood flow of TCD, a statistical significant difference(t-test, P<0.05). (9) By urinary microalbumin, there’s a statistical significance(t-test, P<0.05). (10)By UA, there’s no statistical significance. (11)By blood lipids, a statistical significance between the normal TC group and the abnormal TC group(t-test, P<0.05); and a statistical significance between the normal non-HDL-C group and the abnormal non-HDL-C group as well(t-test, P＜0.05);there’s no statistical significance compared by other blood lipids, including LDL-C, HDL-C, TG (t-test, P>0.05).ConelusionThere is a certain correlation between MBPS and hypertension pathogenesis, blood pressure level. MBPS has a rising tendency with the longer pathogenesis and the higher blood pressure level. And the greater MBPS is, the patient will get easier to has increased urinary microalbumin, which is a sign of early renal damage. The greater MBPS is, the TCD and the IMT will be easier to get abnormal. A certain correlation between MBPS and blood lipids, the average MBPS of the dyslipidemia group is significantly greater than the normal blood lipids groups, especially compared by TC and non-HDL-C. The average MBPS of stagnation of phlegm-dampness type is significantly greater than other TCM syndrome types.