The Association Between Essential Hypertension With Morning Blood Pressure Surge And Target Organ Damage In The Elderly

Objective To investigate the association between the target organ damage and essential hypertension with MBPS in the elderly. Methods We classified 322 patients into the MBPS group (n=173) and the non-MBPS group (n=149), according to their 24h ambulatory blood pressure monitoring profiles. The following characteristics of the participants were assessed at regular intervals: cholesterol,body mass index (BMI),left ventricular mass index (LVMI), carotis endarterium intercellular medium thickness (CCA - IMT and ICA– IMT) and corrected QT dispersion (QTcd). Results 24h,day and night mean systolic blood pressure in MBPS group were significantly higher than that in the non-MBPS group (P<0.05). Compared with the non-MBPS group, the MBPS group had significantly longer QT,QTc,QTdand QTcd (respectively, QT: 370.0±24.6 vs 352.0±32.4, P<0.01; QTc: 414.0±23.7 vs 409.0±31.6, P<0.01; QTd: 32.3±10.5 vs 30.1±12.6, P<0.01; QTcd: 40.2±10.8 vs 37.5±13.9, P<0.01), as well as higher LVMI,CCA–IMT and ICA–IMT(respectively, LVMI: 170.1±16.4 vs 143.5±14.8, P<0.05; RCCA-IMT: 1.5±0.1 vs 0.9±0.2, P<0.05; LCCA-IMT: 1.4±0.1 vs 0.8±0.2, P<0.05; RICA-IMT: 1.3±0.2 vs 0.9±0.3, P<0.05; LICA-IMT: 1.2±0.2 vs 0.8±0.3, P<0.05). Conclusion There were the prolongation of cardiac repolarization times,more severe carotid atherosclerosis and left ventricular hypertrophy in the MBPS patients than that in non-MBPS patients,which might contribute to the progression of carotid atherosclerosis,left ventricular hypertrophy and raised prevalence of arrhythmia.