| ObjectiveThrough retrospective reviewthe clinical data of patients who were diagnosed with dengue fever in Guangdong Province Traditional Chinese Medical Hospital 2014, to explore the clinical characteristics of dengue fever patients with different sex and age, and then further understand the epidemic characteristics of dengue fever, supplement the epidemiological information. At the same time, it also discussed the clinical features of dengue fever patients with different TCM syndrome types, in order to strengthen the monitoring of patients, to better guide the clinical prevention and treatment work, to improve the prognosis of patients with dengue fever.MethodAccording to the purpose of the study and reference, using the Electronic Medical Record system of hospital collect patients who confirmed as dengue fever from June to October 2014 in Guangdong Province Hospital of TCM with general information (name, gender, age, time of onset, previous history), main symptoms and signs and laboratory examination (white blood cell, platelet, liver and kidney function, cardiac enzymes), and then establish a database using Epidata3.0 software, after that lead the datainto SPSS19.0 software, according to the data types and characteristics conduct descriptive analysis, variance analysis, chi square test and fisherexacttest etc.ResunltsCollected a total of 1776 cases of dengue fever patients, of which 861 were male,915 were female, the youngest was 1 years old, the oldest was 96 years old, according to the WHO age hierarchy, all patients stratified by age, 1-18 years wasthe group of children which with 155 patients, percentage of 8.7%,19-60 years was the adult group which with 915 cases, percentage of 64.5%, 475 cases of patients was 61 years and older (age group), the percentage was 26.7%.1. In terms of fever Fever occurred in 1385 patients, and the highest temperature was up to 42℃.The average of the highest temperature for all patients was (38.81±0.80) ℃, moderate fever and ardent fever patients accounted for 47.7%,37.6%respectively. There was significant difference between the different age groups on fever degree, P=0.000. Children group had the highest fever, and the elderly group was the lowest. There was significant difference in the incidence of bleeding in the different fever groups, P=0.032.2. In terms of erythra The incidence of erythra of patients in different age groups was statistically significant,p=O.000. The proportion of erythra in children group and adult group was significantly higher than that in the elderly group, and there was no difference between children and adults.3. In experiment examination Patients in different gender groups, the decrease of white blood cell (P=0.000), the degree of thrombocytopenia (P=0.010), the incidence of renal impairment (P=0.003) have significant differences.The decliningdegree of white blood cell in female group was significantly higher than that of male group, while the degree of thrombocytopenia male group was significantly higher than that of female group, and the patients in male group were more likely to have abnormal renal function. Patients of different age groups in the decrease of white blood cell (p=0.002), thrombocytopenia (P=0.000), renal dysfunction (P=0.000), myocardial injury (p=0.004) had significant difference. The average level of white blood cells of adult group was significantly lower than the elderly group. Among different age groups, the platelet decreasin degree weredifferent, but the elderly group decreased more seriously than the children group and adult group. Renal impairment in elderly patients were more than that in children and adults, and the incidence of myocardial injury in children group was higher than that in adult group. There was a significant difference in the degree of thrombocytopenia and bleeding, P=0.000. The lower the platelet, the risk of bleeding was greater.4. Traditional Chinese Medicine Excluding cases of incomplete, there were 965 cases of patients belong to damp-heat epidemic,602 cases of patients geared to syndrome of summer-dry epidemic, comparison of two kinds of syndrome patients’fever degree, fever days, the minimum value of white blood cells, the lowest platelet values, transaminase elevations, myocardialenzyme, erythra, haemorrhage, the two groups all showed no significant difference. As for renal damage, damp-heat syndrome group occured more easily rhan summer-dry syndrome group, P=0.020.ConclusionPeople are generally susceptible to dengue virus, population distribution was from infants to the elderly. After infecting patients with dengue showed moderate fever or high fever, young people are more likely to developed to high fever. High fever patients with greater risk of bleeding. The erythra more often occurred in young and middle-aged people. Female’s white blood cells decreased significantly than male, but male showed more severely thrombocytopenia than female. The white blood cells of adult group decreased significantly, the elderly group was relatively lenitively decline, however, the elderly patients with platelet decreased more significantly than the children and adult. Platelet declining levelobviously correlated with bleeding. The incidence rates of liver damage in patients of this study was 60.78%, mainly in AST increased. Age and elevated transaminases showed no significant correlation. There was no relationship between the erythra and liver function. Male and elderly patients after infecting dengue more easily appear renal damage. There were differences on myocardial damage in different ages. In terms of Chinese medicine, damp-heat syndrome group occuredrenal damage more easily rhan summer-dry syndrome group. |
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