| Objective:To detect the levels of neonatal 25 (OH) vitamin D, parathyroid hormone, calcitonin hormone, osteocalcin and ultrasonic bone mineral density among 95 cases of the new-born babies and aims to figure out what are the relationship of neonatal bone metabolism related hormones with ultrasonic bone mineral density (BMD).Methods:By collecting the information of the infants.who were born between August 2015 to 2016 January in the second Affiliated Hospital of Kunming Medical University,this study selected 95 infants in strict accordance with the inclusion criteria as the research objects. These infants were grouped by the gestational age, sex. birth weight and whether supple vitamin D regularly in pregnent period. It used the method of chemiluminescence immune analysis for the determination of 25 (OH) VD,magnetic particle chemical chemiluminescence determination of parathyroid hormone, electrochemical luminescence immune analysis method for the determination of calcitonin and osteocalcin.ultrasound bone densitometer determination of bone mineral density. A questionnaire survey was conducted to get the general situation of the newborn, the situation of birth, maternal vitamin D supplementation during pregnancy, lifestyle, disease history, pregnancy historyResults:1.The mean value of 25-(OH) VD in the serum of neonates was 17.4777±8.08909ng/ml. Preterm infants (15.8886±8.08909 ng/ml) and term group (19.2433±8.37038 ng/ml),supple vitamin D regularly during pregnancy (19.626±9.38845ng/ml) and pregnancy without vitamin D regular supplement (15.4093±6.54817ng/ml) for mean comparison. P<0.05, the difference was statistically significant. According to the diagnostic criteria of vitamin D deficiency in children,95 cases of newborns, normal vitamin D were only 30 cases, accounting for 31.58% of the total number of survey, others have a different degree of vitamin deficiency.2. Ultrasonic bone density average value of neonatal was 2832.96±187.070m/s. Preterm infants (2775.12±196.410m/s) and term group (2897.22±154.196m/s), birth weight<2500g group (2752.09±182.256m/s) in associated with birth weight>2500g group (2899.83±164.539m/s), supple vitamin D regularly during pregnancy (2880.26±165.012m/s) and pregnancy without vitamin D regular supplement (2780.40±197.665m/s) for mean comparison, P<0.05, the difference was statistically significant. According to the children’s bone strength level diagnostic criteria,95 cases of bone strength in premature infants health were only 18 people, accounting for the neonatal research number 18.95%.3. The mean value of PTH in neonates was 101.9180±69.88312pg/ml. Preterm infants (115.5848±78.84175pg/ml) and term group (86.7327±55.34238pg/ml), birth weight< 2500g group(131.4926±81.52461) in associated with birth weight>2500g group (77.4621±46.69662pg/ml), supple vitamin D regularly during pregnancy (87.5268±52.01262pg/ml) and pregnancy without vitamin D regular supplement 117.9028±83.20861) for mean comparison, P<0.05, the difference was statistically significant.4. The mean value of CT in neonates was 11.1666±7.44535pg/ml. Preterm infants (9.7436±6.84857pg/ml) and term group 12.7478±7.83166pg/ml), birth weight< 2500g group (9.1260±5.83010pg/ml) and birth weight≥2500g group (12.8540± 8.23197pg/ml) to compare the mean,P< 0.05, the difference was statistically significant.5. The mean value of BGP in neonates was 84.5135±28.29934ng/ml. Preterm infants (76.9540±30.78589ng/ml) and term group (92.9129±22.76727ng/ml), birth weight <2500g group (74.0984±24.28356ng/ml) in associated with birth weight≥2500g group (93.1260±28.69435ng/ml) to compare the mean,P<0.05, the difference was statistically significant.6. The correlation between neonatal serum 25 (OH) VD, PTH, CT, BGP and BMD analysis,25-(OH) VDand BMD correlated, r=0.279, P=0.006,25-(OH) VD and BMD was positive correlation.Conclusion:1 Among 95 cases of infants,65 cases (68.4%) with vitamin D deficiency,77 cases (81.1%) were with low bone density, the smaller the gestational age, the lower the value of vitamin D and bone density, the smaller the birth weight, the lower the value of bone density.2 Maternal vitamin D supplementation during pregnancy can effectively improve the level of vitamin D and bone mineral density, and reduce the level of PTH.3 Neonatal PTH,CT and BGP related to gestational age and birth weight.CT and BGP were higher in the newborn, the lower the age, the lower the birth weight, the higher the PTH, the lower the CT and BGP.4 Neonatal bone mineral density was positively correlated with 25-(OH) VD,no correlation with CT, BGP and PTH. |
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