The Characteristics Of Colorectal Adenoma Polyps And The Role Of Interleukin6,Interleukin 10 In Colorectal Polyps Canceration

ObjectiveThrough case control study, comparing incidence rate of different risk factors among different pathological types pathological types,finding the risk factors in polyp canceration and providing the basis for screening colonoscopy.MethodsPatients who suffering from colon polyps between May 2014 and September 2015 and at the department of Gastroenterology and Gastrointestinal Surgery,Affilitated Hospital of Jining Medical University,were anlyzed.the information including age, sex,height, weight,body mass index,history of diabetes、 hypertension、gastric polyps、endometrial polyps, coronary artery disease, Family history of cancer,triglycerides and total cholesterol value,collect endoscopic polyp location, size,number and pathology,anlyze the sample data.Results1.The proportion of stool symptoms in advanced adenoma polyp group was 33.3% (18/54), higher than the proportion of non-adenoma pilyp group 11.3% (21/186), the difference was statistically significant (X2= 14.94, P= 0.00).2.Advanced adenoma polyp group with a history of diabetes was 18.52%(10/54), the proportion is higher than the proportion of non-advanced adenoma polyp group 8.60%(16/186), the difference was statistically significant (X2= 4.260, P= 0.039).3.Advanced adenoma polyp group mean BMI was 25.02±3.61kg/m2, higher than the non-advanced adenoma group mean BMI was 23.92 ± 3.50kg/m2, the difference was statistically significant (t=1.997,P<0.05). Triglycerides in advanced adenoma polyp group was 1.88±1.19mmol/L, higher than the non-advanced adenoma group of triglycerides with an average of 1.52±1.03mmol/L, the differences was statistically significant (t=2.199,P<0.05).4.The proportion of family history of cancer in advanced adenoma polyp group was 31.48%(17/54), higher than the proportion of non-advanced adenoma group was18.82%(35/186), (X2= 3.955, P= 0.047).5.The risk factors of advanced adenoma polyps are blood in stool(P=0.03 4), triglyceride>5.85mmol/L(P=0.015),BMI≥24.8kg/m2 (P=0.048),parental history of cancer (P=0.023);The risk factors are as follows:blood in stool(OR=2.589,9 5%CI:1.074-6.244),parental history of cancer (OR=2.437,95%CI:1.134-5.238),trigl yceride>5.85mmol/L (OR=2.26,95%CI:1.171-4.362),BMI≥24.8kg/m2 (OR=1.96 3,95%CI:1.006-3.831)ConclusionPatients with stool, triglycerides>5.85mmol/L,and BMI≥24.8kg/m2,family history of cancer are risk factors of advanced adenoma..ObjectiveComparing the positive expression rate and mRNA expression level of IL6,IL10 in different pathological types of s CAP,colorectal cancer, normal adjacent,to explore the role of inflammatory mediators in the carcinogenesis of cap and provide guidance for clinical diagnosis and treatment.MethodsTotal 169 patients with different pathology types of colorectal tissues were collected during May 2014 and November 2014 in Affiliated Hospital of Jining Medical University. IL6,IL 10 expression in tissues were detected using Real-Time Fluorescent Quantitative PCR and immunohistochemistry.Results l.the relative expression of IL6 mRNA in adenocarcinoma was 2.951 ±0.474,higher than villous adenomas(1.763 ±0.143), tubular villous adenoma s(1660± 0.119), tubular adenomas (1.603±0.136) and normal tissues (1.000±0.000) (F=27.309, P< 0.05), at the same time,the relative expression quantity decrease gradually. 2.The positive expression rate of IL6 protein in adenocarcinoma was 72.41%, which was higher than that in adenomatous polyps,normal colorectal tissues (43.24%, 10.34%) (X2=22.916, P＜0.05).3.The relative expression of IL10 mRNA in carcinoma was3.516±0.337, higher than vilous adenomas (1.577±0.160), tubular-villous adenomas(1.538±0.077), tubular adenomas(1.473±0.134) and normal tissues (1.000±0.000), (F=89.919, P< 0.05).4.The positive expression rate of IL10 protein in adenocarcinoma was 82.76%, which was higher than that in adenomatous polyp,normal tissues (44.59%,13.79%) (X2=27.923, P<0.05).ConclusionIL-6, IL-10 may play a role in the progress of normal tissue-adenoma polyp-adeno carcinoma, but in normal tissue-hyperplasia polyposis-serrated adenoma canceration progress was no obvious effect.