Effect Of Preoperative Peripheral Blood Neutrophil-to-lymphocyte Ratio And Platelet-to-lymphocyte Ratio On Diagnosis And Prognosis Of Patients With Clear Cell Renal Cell Carcinoma

Objective: To evaluate the effect of preoperative peripheral blood neutrophil-to-lymphocyte ratio(NLR) and platelet-to-lymphocyte ratio(PLR) on diagnosis and prognosis of patients with clear cell renal cell carcinoma(ccRCC).Methods: The clinical data of 151 ccRCC and 63 angiomyolipoma(AML) cases newly diagnosed and confirmed by postoperative pathology were analyzed retrospectively and all of them were followed-up.The optimal cut-off value of NLR and PLR to discriminate between AML and ccRCC,as well as different clinical stages,was obtained by ROC.In ccRCC, high level NLR and PLR were divided basing on the cut-off value of NLR and PLR, and various clinical factors were evaluated respectively by univariate analysis using t test, Kaplan-Meier, Log-rank or cox proportional hazards regression analysis.Results: NLR and PLR value were(1.57±0.45) and(112.34±36.64) in AML group,(2.74±1.48)and(143.46±65.80) in ccRCC group,(P<0.05).The best cut-off value of NLR and PLR were 1.92 and 102 to discriminate between AML and ccRCC by ROC curve. In ccRCC patients, Univariate analysis showed that clinical stage, ECOG score, NLR, PLR and NLR-PLR score were prognostic factors.Multivariate analysis showed that clinical stage and NLR-PLR score were independent prognostic factors of ccRCC.Conclusions: Preoperative peripheral blood NLR and PLR may be helpful to differentiate between AML and ccRCC. Clinical stage and NLR-PLR score may be independent poor prognostic factors of ccRCC.