Optical Coherence Tomography Angiography Of Peripapillary Vessel Density In Glaucoma

Objective: To investigate the clinical significance of peripapillary vessel density determined by Angio-OCT in glaucoma.Methods: Observational study performed from July, 2015, to November, 2015. In total,31 glaucomatous eyes and 16 normal eyes were analyzed. The optic disc region was imaged using optical coherence tomography angiography. In this study, peripapillary vessel density was defined as the ratio between micro vascular coverage area and the rest of the area that except for the area of the great vessels.Results: In 16 normal eyes, a dense micro vascular network around the disc was visible on OCT angiography. In 31 glaucomatous eyes, this network was visibly attenuated globally and focally. Difference was significant and t=2.229, p=0.032.Peripapillary vessel density were highly correlated with visual field, intraocular pressure and cup disc radio(p=0.049,p=0.038,p=0.012. Determination coefficient R2= 0.529.Conclusion: Peripapillary vessel density were highly correlated with visual field,intraocular pressure and cup disc radio. These indicators can reflect the condition of patients with glaucoma. Quantitative OCT angiography may have value in future studies to determine its potential usefulness in glaucoma evaluation.