Computer Simulation Research And Experiment Of Ultrasonic Transdermal Drug Delivery Mechanism

With the protein polypeptide drugs and other new drugs having been developed and widely used in the prevention, diagnosis and treatment of disease, traditional approaches of oral and parenteral administration are increasingly showing their shortcomings. Better therapeutic effect, more convenient and much safer ways of administration have become a hot research topic. As an important method of transdermal drug delivery, sonophoresis with little irritation to the skin does not destroy the pharmacological properties, which has attracted widespread attention and has very important research value.The main mechanism of sonophoresis is ultrasonic cavitation effects. The cavitation bubbles collapse instantaneously producing large amounts of energy that can damage the skin barrier function of the stratum corneum. At present, the relationship between ultrasonic frequency, intensity and the effect of penetration are summarized based on experiments with the lack of relevant quantitative model of ultrasound transdermal drug delivery research. So the numerical value analysis of the relationship between ultrasonic frequency, intensity and the effect of penetration is reported rarely.Based on this background, this paper carried out the following work:1. This paper is based on the mechanism of ultrasonic transdermal drug delivery, principle of cavitation effects, numerical study of acoustic cavitation bubble dynamics and the Rayleigh-Plesset equation, presenting the ultrasonic excitation signal and the cavitation bubbles sports-related mathematics equation model. Besides, Matlab mathematical software is used to numerically solve the motion simulation of the cavitation bubbles.2. The simulation results under different ultrasonic frequencies and different ultrasonic intensity are analyzed to obtain the influence of frequency of the ultrasound excitation and intensity parameters on sonophoresis effect. According to the results of the simulation analysis, the author also discuss the principles of dual-frequency sonophoresis.3. Ultrasonic transdermal insulin delivery experiments for living rats are used to research the effects of low frequency ultrasound to promote transdermal peptide drug transport and verify lower frequency ultrasound has a better penetration effect. The design of ultrasonic signal transmission system to achieve a variety of frequency and adjustable amplitude for ultrasonic emission. Besides, the security of clinical applications at low-frequency ultrasound transdermal delivery are discussed.Applying the numerical study of cavitation to the analysis of ultrasonic signal and ultrasonic transdermal drug effects, on the basis of the relationship between ultrasonic excitation signal and the cavitation bubbles movement, we further analyze the effect of ultrasonic frequency and intensity parameters on sonophoresis. This approach has certain innovative points and for the quantitative analysis of ultrasonic transdermal drug delivery research, which also has research value.