Database Construction And Meta-analysis For Sepsis Biomarker

Sepsis is the leading cause of death for the patients in intensive care units(ICUs). But the diagnosis and prognosis for sepsis is still a challenge. Biomarkers are considered having the ability to improve this situation. Along with more and more scientists begin to focus on the biomarkers studies, plenty of sepsis biomarkers have been identified in clinical experiments. But there was not an aggregate for all these sepsis biomarkers, so it wasted much time for people to find out the information of their needed biomarkers. Based on this, we constructed the Meta SepsisBase(website: http://sysbio.suda.edu.cn/SBD/), the first integrative and interactive database for sepsis biomarker, which concludes all the 287 identified sepsis biomarkers’ information. The main function of MetaSepsisBase is to collect, store and display the details of information about sepsis biomarkers, and through which users can also submit new identified markers to us.From the MetaSepsisBase we learn that there are 63 diagnostic biomarkers for neonatal sepsis(NS), but many studies confirmed that these individual markers were inadequate for the diagnosis of NS. To address this issue, an integrated meta-analysis which covered the network and diagnostic meta-analysis was designed to evaluate the diagnostic value of C-reactive protein(CRP) and Mean neutrophil volume(MNV) in the early diagnosis of neonatal sepsis. The area under summary receiver operating characteristic curves(AUC) for CRP-MNV, CRP, MNV are 0.9352, 0.8380, and 0.8794, respectively. Our results suggest that CRP-MNV as combined makers shows better diagnosis values than using CRP or MNV alone in NS. Therefore, the integrated meta-analysis of combined markers could provide a valuable additional tool for the diagnosis of complex disease in the future studies.