Safety And Efficacy Of Intermittent Pneumatic Compression In The Treatment Of Deep Venous Thrombosis

Objective: To investigate the safety and efficacy of intermittent pneumatic compression(IPC) in the treatment of deep venous thrombosis(DVT). Methods :The clinical data of 496 patients with DVT who were treated in our hospital from January 2014 to October 2010 were analyzed retrospectively,comparison the time of each type of acute, sub-acute and chronic phase patients accepted simple treatment(anticoagulant therapy, systemic thrombolysis or catheter thrombolysis) and simple treatment combined with IPC treatment with venous pressure decreased to normal time(T1) and diameter difference decreased to normal time(T2) in patients,comparison the recurrence about the pulmonary arterial embolization(PE) and DVT in patients who received treatment with simple therapy(control group) and with IPC(combined group). Results:For patients in acute stage,patients in central type, peripheral type and mixed type,the time ofT1 and T2 in combination group were significantly shorter than that in the experimental group(P<0.05).For patients in sub-acute stage,patients in central type and mixed type,the time of T1 and T2 in combination group(anticoagulant therapy/systemic thrombolysis+IPC) were significantly shorter than that in the experimental group(anticoagulant therapy/systemic thrombolysis)( P<0.05),however,patients in peripheral type,the time of T1 in combination group(anticoagulant therapy/systemic thrombolysis+IPC) was significantly shorter than that in the experimental group(anticoagulant therapy/systemic thrombolysis)(P<0.05),but,there was not statistical significance about the time of T2 in combination group(anticoagulant therapy/systemic thrombolysis+IPC) and the experimental group(anticoagulant therapy/systemic thrombolysis)(P>0.05).For patients in chronic stage,patients in central type and mixed type,there were not statistical significance about the time of T1 and T2 in combination group(anticoagulant therapy+IPC) and the experimental group(anticoagulant therapy)( P>0.05);Patients in peripheral type,the time of T1 in combination group(anticoagulant therapy+IPC) was significantly shorter than that in the experimental group(anticoagulant therapy)(P<0.05),but,there was not statistical significance about the time of T2 in combination group(anticoagulant therapy+IPC) and the experimental group(anticoagulant therapy)(P>0.05).There are 63 patients in control group and 47 patients in combined group who had PE before treatment,there are 56 patients whose Symptoms were relieved after treatment in control group,however, there are 0 patients whose symptoms were aggravated after treatment in control group.(The other 7 patients had no obvious changes before and after treatment),the remission rate was 88.89%;There are 44 patients whose symptoms were relieved after treatment in combination group,however, there are 0 patients whose symptoms were aggravated after treatment in combination group(The other 3 patients had no obvious change before and after treatment),the remission rate was93.62%,there were statistically significant about the remission rate of PE in the 2 groups,the combination group had a higher remission rate(P<0.05). There are 6 patients of new PE in the control group after treatment in patients who had PE before treatment,the PE occurrence rate was 4.26%(6/141),there are no patients of new PE in the combination group after treatment,there were statistically significant about the new hair of PE in the 2 groups.325 cases of patients were followed up after hospital,the time of follow up was 3~36 months,median time was 27 months,combination group is lower than control group,there were 157 patients in the control group and 168 patients in the combination group,there were 74 patients were recurred in the control group,the recurrence rate was 47.13%,there were 46 patients were recurred in the combination group,the recurrence rate was 27.38%,there were statistically significant about the recurrence rate in the 2 groups,combination group is lower than control group(P<0.05).As long as the patients with superficial venous expansion, lower leg skin pigmentation, ulcers are considered to form PTS,there were 27 patients were formed PTS in the combination group,the PTS occurrence rate was 9.25%,there were 41 patients were formed PTS in the control group,the PTS occurrence rate was 20.98%,there were statistically significant about the PTS occurrence rate in the 2 groups,combination group is lower than control group(P<0.05). Conclusions: IPC significantly shortened the time of venous pressure and the lower limb circumference to normal in the majority of patients with DVT,reduced the recurrence rate of the patients,relieved the clinical symptoms of PE.Therefore, IPC is a safe, reliable and effective treatment for most patients with DVT.