| Objective:To study the relationship between the gastric polyp of TCM syndrome type and its pathological types and serological indexes TK1 and the CEA, explore the internal connection between the "card" of traditional Chinese medicine and modern medicine pathology and the serology indexes.Methods:1. Through the literature research and expert consultation, forming the gastric polyps clinical information questionnaire (seeing the appendix)2. Collect cases data:For the patients with gastric polyps which conform to the inclusion criteria and agree to participate in the survey of patients with gastric polyps, we collect general information, truthfully filling in the questionnaire. Through the four diagnostic parameter, according to the TCM diagnostic criteria, obtain the traditional Chinese medicine syndrome types. Sending blood samples of all patients to the hospital clinical laboratory to detect the TK1 and CEA level. Signing gastric polyp excision of informed consentbfore gastric polyps resection. After gastric polyps resection, all polyps tissue have the pathological tests and we record its pathological types.3. Analyzing of 134 cases of gastric polyps the distribution characteristics of TCM syndrome types and pathological types.4. To compare 134 cases of gastric polyps relationship between TCM syndrome type and biopsy pathology type5. To discuss the relationship of the TCM syndrome type of of gastric polyps between the pathological types and TK1 and CEA levels. Results:1. Gastric polyp disease in middle-aged and old, with an average age of 54.35+/-11.73 years of age, incidence of male was higher than female, male to female ratio is 1.16:1.2.134 cases of gastric polyps in patients with spleen deficiency cold syndrome,10 cases (7%), followed by wet aggregates the 7 cases (5%), taste hot and damp card 41 cases (31%), liver depression and qi stagnation syndrome, 25 cases (19%), followed by wet stasis 41 cases (31%),4 cases of qi and blood stasis syndrome (3%), and 6 cases of phlegm syndrome (4%). Many women with liver depression and qi stagnation, men is given priority to with spleen and stomach hot and humid, young and middle-aged patients with rare taste hot and humid and liver depression and qi stagnation syndrome, and older patients is given priority to with wet stasis pixu (spleen deficient).3.134 cases of gastric polyps in patients with inflammatory polyp 59 patients (44%, male 36, female 23 cases), hyperplastic polyp 21 cases (15%, 7 patients were male, female 14 cases),24 cases of adenomatous polyps (18%, male 18 cases, female 6 cases), gland polyps in 5 cases (4%,2 were male, female 3 cases), mixed polyp 21 cases (16%,6 cases of male and female 15 cases), 4 cases were histologically negative polyps (3%,3 were male, female 1 case), the male is given priority to with inflammatory polyp and adenomatous polyp, women with inflammatory polyp, hyperplastic polyp and mixed polyp is given priority to. Different pathological types of polyps in the distribution of all ages have no difference.4. Gastric polyps existed correlation between TCM syndrome type and pathological type, adenomatous polyp and inflammatory polyp is given priority to with wet stasis and taste hot and humid pixu (spleen deficient), showed that wet stasis, hot and humid environment is related to the formation of pathology, with hyperplastic polyp with liver depression and qi stagnation, spleen and stomach, damp and hot is given priority to, and qi stagnation, damp and hot is their main pathological factors.5. The relationship between The traditional Chinese medicine syndrome type, pathological type and TK1 and CEA levels:For the comparison of different TCM syndrome types and the TK1 and CEA level, there were no significant differences.In the 7 kinds pathological types of gastric polyps adenomatous polyp has the highest TK1 and CEA levels. Comparing with histological negative polyps, different pathological type in TK1 level has a statistically significant difference (P< 0.05), the different pathological type (except gland polyps) in CEA level also has a statistically significant difference (P< 0.05).Conclusion:1. Gastric polyp disease in middle-aged and old, incidence of male was higher than female.2. the distribution of TCM syndrome type:taste hot and damp card> wet stasis syndrome pixu (spleen deficient)>liver depression and qi stagnation syndrome > spleen deficiency cold syndrome> wet aggregates pixu (spleen deficient)> and phlegm syndrome> qi and blood stasis. Women with liver depression and qi stagnation, male is given priority to with spleen and stomach hot and humid. Young and middle-aged patients with rare taste hot and humid and liver depression and qi stagnation syndrome, and older patients is given priority to with wet stasis pixu (spleen deficient).3. The pathological types distribution characteristics:inflammatory polyps most, followed by adenomatous, mixed polyps, hyperplastic polyp, gland polyps, histology negative polyps. The male is given priority to inflammatory polyp and adenomatous polyp, while women inflammatory polyp, hyperplastic polyp and mixed polyp. Different pathological types of polyps in the distribution of all ages have no difference.4. Gastric polyps existed correlation between TCM syndrome type and pathological type, adenomatous polyp and inflammatory polyp is given priority to with wet stasis and taste hot and humid pixu (spleen deficient), showed that wet stasis, hot and humid environment is related to the formation of pathology, with hyperplastic polyp with liver depression and qi stagnation, spleen and stomach, damp and hot is given priority to, and qi stagnation, damp and hot is their main pathological factors.5. The relationship between The traditional Chinese medicine syndrome type and TK1 and CEA levels:there were no significant differences between them.6. The relationships of the pathological types and TK1 and CEA levels: comparing with histological negative polyps, different pathological type TK1 level has a statistically significant difference (P< 0.05), the different pathological type (except gland polyps) CEA level also has a statistically significant difference (P< 0.05). Seven kinds of gastric polyps pathological type, adenomatous polyp TK1 and CEA content is the highest, showing TK1 and CEA can be used as a testing index of gastric polyp canceration. TK1 and CEA levels of Hyperplastic polyp just littler than adenomatous polyp, suggest possibly hyperplastic polyp have become cancerous. |
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