| ObjectiveTo explore the autoimmune disorders and the risk of diminished ovarian reserve in patients with kidney deficiency syndrome in rheumatoid arthritis.MethodsThere were 320 RA patients included in this study, which was divided i nto two groups:kidney deficiency group and non kidney deficiency group. St atistical analysis between the two groups in gender, age of onset, disease duration, rheumatoid factor and anti-CCP antibodies were made. At the same time, collecting 37 RA female patients who were aged 18-40 years and witho ut previous tripterygium preparation treatment as the case group,30 healt hy women volunteers as the control group. Their peripheral blood samples w ere collected for detecting the level of anti-Mullerian hormone. The risk for diminished AMH levels between the two groups were analyzed. Besides, in case group, the correlation between the risk for diminished AMH levels an d their age, disease duration, number of swollen joints, number of tender j oints, erythrocyte sedimentation rate, C-reactive protein,DAS28 score, immu ne globulin G and immune globulin M were made statistical analysis.Results1. This study included kidney deficiency group(159 cases) and non kidney deficiency group(161 cases). The sex composition of the two groups was compared and the result showed the difference was not statistically significant(P> 0.05).2. The average disease duration of kidney deficiency group was 129.08+129.48 months, which was significantly higher than that of the non kidney deficiency group (95.31 ± 74.91months). The comparison showed the difference was statistically significant(P=0.005<0.05).3. The average age of onset of kidney deficiency group was 50.96±13.21 years old, which was significantly higher than that of the non kidney deficiency group (40.63±13.21 years old). The comparison showed the difference was statistically significant(P=0.000<0.05).4. The average RF titer of kidney deficiency group was 685.89±1215.49 IU/mL, which was significantly higher than that of non kidney deficiency group (524.09 ±835.39 IU/mL).The comparison showed the difference was not statistically significant(P=0.166>0.05). The average anti CCP antibody titer of kidney deficiency group was 127.50±80.46U/mL, which was significantly higher than that of non kidney deficiency group(107.38±82.37IU/mL). The comparison showed the difference was statistically significant (P=0.039<0.05). Compared with non kidney deficiency RA patients, the risk of both autoantibodies positive (both RF and anti CCP antibody were positive) in kidney deficiency RA patients was 3.29 and the 95% confidence interval was [1.03-10.49],P=0.04, which was statistically significant.5. This study included 37 female RA patients as the case group and 30 healthy control group. The average age of the case group was 31.78±6.10 years old and the average AMH level was 2.87±4.98mg/L. While the average age of the healthy control group was 25.70±3.51 years old and the average AMH level was 2.86±3.66mg/L. Compared with the healthy control group, the risk for diminished AMH level in the case group was 19.773 and the 95% confidence interval was [2.424-161.261], P=0.000, which was statistically significant. 6. In the case group, the diminished AMH level was not correlated with the disease activity factors (number of swollen joints, number of tender joints, erythrocyte sedimentation rate, C-reactive protein and DAS28 score) and immune function indexes (IgG, IgM), which was not statistically significant (P>0.05).Conclusion1. The kidney deficiency may aggravate the state of immune disorders in rheumatoid arthritis, which leads to increased autoantibodies.2. The kidney deficiency syndrome may be one of the risk factors for the diminished ovarian reserve in rheumatoid arthritis. |
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