Graft-Versus-Tumor Effect In Mice Liver Transplantation

Objective:It is currently known that liver transplantation has become one of the main method for liver carcinoma.However, there are still reports about recurrence after livertransplantation. A phenomenon known as the graft-versus-tumor (GVT) effect has been found in allogeneic stem cell transplantation, which can reduce the risk of recurrence. This research is to study the GVT effect in mice liver transplantation.Method:We performed a tumor recurrence experiment on mouse liver transplantation model to study the GVT effect. Through comparing the allogeneic group with the autogenic group, the existence of GVT effect can be proved. Then, we used liver transplantation combined with bone fragment transplantation and liver transplantation with donor pre-sensitized to explore the influencing factors of GVT effect.Result:We found tumor growth was inhibited in the allogeneic group, but the effect disappeared in 2 weeks.The effect was not promoted through liver transplantation combined with bone fragment transplantation. The effect would be enhanced by pre-sensitized, but still exited for 2-3 weeks.Conclusion:The result prove the existence of GVT effect in the allogeneic liver transplantation, but the effect can’t last too long. Our trying to promote the effect seems not efficient.