| Objective:190 cases of hepatocellular carcinoma (primary liver cancer, PLC) patients were retrospectively analyzed to obtain its general information, past medical history, family history, treatment, laboratory tests, survival time, and TCM treatment and other information, the initial establishment PLC database information to explore PLC patients with TCM syndrome type features. Analysis of the relationship between the distribution ratios PLC TCM and TCM type of the syndrome and laboratory parameters and survival time, aims to provide a reference for clinical liver cancer research and standardization of traditional Chinese medicine treatment.Methods:From January 2008 to December 2015 in Jiangsu Provincial Hospital of Infectious Diseases, gastroenterology, oncology and other medical records department of the hospital patients, met the inclusion criteria were 190 cases. All cases were confirmed by clinical or radiological examination. According to the unified design of the "primary liver cancer clinical questionnaire" on hospital medical records were recorded, including patient information 1. The patient’s basic information, including gender, age, medical history, family history, to take treatment; 2 laboratory parameters:serum alanine aminotransferase (ALT), globulin (GLB), the white ball ratio (A/G), alpha-fetoprotein (AFP); 3 lifetime:collect the majority of cases the patients died in hospital, a few follow-up indeed ward know the date of death, we have a clear survival time statistics; 4-hospital treatment of TCM and entry, use SPSS 13.0 statistical software to do statistical analysis, the TCM Syndrome distribution PLC and related factors in patients with TCM syndrome relationship between the relevant conclusions, and using statistical software to verify whether there are statistically significant.Result:1. General information on the survey, the number of men suffering from PLC 161, the total number of 84.7%, the number of women 29, the total number of 15.3%,male to female ratio is about:5.55:1.2. In the history of the distribution of PLC patients,76.3% had a family history of PLC 17, previous HBV infected 145 people, the total number,6.8% HCV infected 13 people, the total number, the rest distributed in PBC history one cases of schistosomiasis-induced liver disease in 2 cases. Cirrhosis basis by 123 people, the total number of 64.7%, of which 99 cases of liver cirrhosis, hepatitis C after liver cirrhosis in 13 cases. In PLC patients, HBV infection index positive rate of five order of:HBcAb (75.8%)> HBsAg (65.8%)> HBeAb (47.9%)> HBsAb (15.3%)> HBeAg (10%), which HBcAb, HBsAg, HBeAb significantly higher proportion than the other two, accounting for 75.8% HBV, respectively, of the total number,65.8%,47.9%, and 15.3% HBsAb, HBeAg each HBV total number of 10%. The number of patients with hepatitis B "HBeAg" 18 "positive" 80, "positive" significant increase over the "big three" number of patients.3.190 patients surveyed,37.9 per cent blood stasis type, heat Accumulation type accounted for 25.3%,22.6% liver-kidney, liver and spleen deficiency accounted for 13.7%.4.PLC patients with ALT Sort:liver and kidney> blood stasis> heat Accumulation> liver and spleen, liver spleen and liver and kidney were statistically significant, liver and spleen and stagnation, Damp Results showed no statistical significance. GLB Sort:liver spleen> stagnation> liver and kidney> heat Accumulation, no statistically significant difference between groups. A/G Sort:heat Accumulation> liver spleen> stagnation> liver and kidney, four groups were lower than normal, appears white ball than the upside, liver and kidney and liver spleen and blood stasis Comparison statistically significant. AFP Sort:heat Accumulation> liver and kidney> blood stasis> liver spleen, no statistically significant difference between groups.5. Survival time Sort:liver spleen> stagnation> heat Accumulation> liver and kidney, liver and spleen and blood stasis, heat Accumulation liver and kidney have more statistical significance, blood stasis and heat Accumulation, liver and kidney have more statistical significance, heat Accumulation and liver and kidney showed no statistical significance.6.AFP value and survival time was weakly correlated to calculate the Pearson correlation coefficient, linear correlation hypothesis two overall, the conclusion that a P value of 0.19, greater than 0.05, the assumption does not hold, AFP value and survival time linear correlation relationship.Conclusion:1. On investigation PLC gender distribution, men significantly more than women.2. PLC patients suffering from chronic hepatitis to cirrhosis and multi-person basis, and cirrhosis of the liver caused by hepatitis majority; in chronic hepatitis B patients, the "positive" the number of patients was significantly higher than that. " HBeAg "number of patients.3. TCM Syndrome PLC, the majority of empirical to blood stasis type; liver-kidney deficiency to the majority.4.PLC ALT levels in patients with liver and kidney was higher than the other three groups, A /G level of the liver and kidney was lower than the other three groups. AFP between groups was not statistically significant.5. Comparison of liver and spleen survival time than the other three groups, four groups of survival time varied.6.AFP has a weak correlation with the survival time. |
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