Relationship Between TCM Symptom-Differentiation Types And Clinical Lab Tests

[Objective]:To research the relationship between TCM symptom-differentiation types and clinical lab tests.[Methods]:1. Literature review : Review the relevant literature and papers on TCM symptom-differentiation types, so as to asses the modern researches on TCM symptom-differentiation types of lung cancer.1.Clinical study: 60 lung cancer patients was arranged in to 5 groups according to TCM diagnostic criterial, which are internal heat due to yin deficiency, deficiency of both yin and yang, qi stagnation and blood stasis, deficiency of both qi and yin, spleen-deficiency and phlegm-turbid stagnation. Every patients’ PS score were recorded. Blood routine analysis instrument, automatic biochemical analyzer and automatic blood coagulation analyzer were applied to check the WBC count, RBC count, Hb concentration,hepatic function(including ALT, AST, ALP, GGT, TP, GLOB, ALB, TBIL, DBIL, IBIL and TBA), kidney function(including Urea, Cr, Ua and LDH), blood Glu, blood lipoids(including Tg, Chol, Ldl-C, Hdl-C, Apo A1, Apo B),cancer marker(including CEA, NSE, CA12-5 and CA19-9), nutrition protein(including TF, PA, FER and RBP), coagulation function(including PT, INR, Fib, APTT, TT and D-Dimer) of each patients in every TCM Symptom-Differentiation Types of lung cancer. All the dates was input into database, statistic soft ware Graph Pad Prism 5.0 was applied to analysis the relationship between TCM Symptom-Differentiation Types of lung cancer and clinical lab tests.[Results]1. Literature research: The research on TCM Symptom-Differentiation Types of lung cancer has very important value for accurate diagnosis, treatment guideline, judgment of prognosis. There is big amount of researches on TCM Symptom-Differentiation Types of lung cancer and modern tests. internal heat due to yin deficiency and deficiency of both yin and yang seems to be more frequently seen in advanced stages of lung cancer patients, whose immune function etc. are comparatively poor than other types, which indicates worse prognosis. However, since the TCM Symptom-Differentiation Types of lung cancer is not unified, bias are existed in some researches.2. Clinical study:For PS score, deficiency of both yin and yang > internal heat due to yin deficiency > deficiency of qi and yin(P<0.05)> qi stagnation and blood stasis(P<0.05)> spleen-deficiency and phlegm-turbid stagnation(P<0.001). Statistical differences are occurred by comparing with goup of deficiency of both yin and yang.For WBC count, deficiency of both yin and yang > internal heat due to yin deficiency > spleen-deficiency and phlegm-turbid stagnation(P<0.05) > qi stagnation and blood stasis(P<0.05)> deficiency of qi and yin(P<0.01). Statistical differences are occurred by comparing with goup of deficiency of both yin and yang.For Hb concentration, internal heat due to yin deficiency < deficiency of both yin and yang < qi stagnation and blood stasis < deficiency of qi and yin, spleen-deficiency and phlegm-turbid stagnation(P<0.05). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.For serum ALB concentration, internal heat due to yin deficiency < deficiency of both yin and yang < qi stagnation and blood stasis < deficiency of qi and yin < spleen-deficiency and phlegm-turbid stagnation(P<0.05). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.For serum LDH concentration, deficiency of both yin and yang is higher than all other four groups(P<0.001).For serum Urea concentration, qi stagnation and blood stasis < deficiency of qi and yin(P<0.05).For serum UA concentration, internal heat due to yin deficiency < deficiency of both yin and yang < qi stagnation and blood stasis < deficiency of qi and yin < spleen-deficiency and phlegm-turbid stagnation(P<0.01). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.For blood Glu concentration, internal heat due to yin deficiency > deficiency of both yin and yang > qi stagnation and blood stasis > deficiency of qi and yin > spleen-deficiency and phlegm-turbid stagnation(P<0.05). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.For serum CEA concentration, internal heat due to yin deficiency > deficiency of both yin and yang > qi stagnation and blood stasis > deficiency of qi and yin > spleen-deficiency and phlegm-turbid stagnation(P<0.05). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.For serum CA125 concentration, internal heat due to yin deficiency > qi stagnation and blood stasis > deficiency of both yin and yang( P<0.001) > spleen-deficiency and phlegm-turbid stagnation(P<0.001)> deficiency of qi and yin(P<0.001). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.For serum CA19-9 concentration, internal heat due to yin deficiency > deficiency of both yin and yang > qi stagnation and blood stasis > spleen-deficiency and phlegm-turbid stagnation(P<0.05) > deficiency of qi and yin(P<0.05). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.For serum D-Dimer concentration, internal heat due to yin deficiency > deficiency of both yin and yang, qi stagnation and blood stasis > spleen-deficiency and phlegm-turbid stagnation( P<0.05) > deficiency of qi and yin(P<0.05). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.For serum TF concentration, internal heat due to yin deficiency < deficiency of both yin and yang < qi stagnation and blood stasis < deficiency of qi and yin < spleen-deficiency and phlegm-turbid stagnation(P<0.05). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.For serum FER concentration, internal heat due to yin deficiency > deficiency of both yin and yang, deficiency of qi and yin > qi stagnation and blood stasis > spleen-deficiency and phlegm-turbid stagnation(P<0.05). Statistical differences are occurred by comparing with goup of internal heat due to yin deficiency.[Conclusion]:1. Both literature review and our research showed: Deficiency of both yin and yang and internal heat due to yin deficiency are two types of TCM Symptom-Differentiation Types of lung cancer that have more serious clinical signs; the lab tests showed higher PS score, WBC count, D-Dimer concentration and tumor markers in these two groups, While lower serum ALB, Hb. By the contrast, groups of deficiency of qi and yin, qi stagnation and blood stasis, spleen-deficiency and phlegm-turbid stagnation are in better condition.2. Lab tests are benefit to recognize the essence of TCM Symptom-Differentiation Types lung cancer. Most lab tests available could be equivalent to “holistic view” in TCM, and applied to reflect individual status.3. There is no lab tests available to sensitive enough to correspond with TCM Symptom-Differentiation Types of lung cancer.