| Objection: Use perfusion parameters of dual-source CT to evaluate the effections of TACE that treats the HCC.Method : 23 cases of the advanced HCC which had been confirmed by liver pathology,erology and imaging without any treatment,that consists with Barcelona(BCLC)criteria for diagnosis of HCC,with the percontrast、postcontrast triple-phase of dual-source CT low dose scaning and the whole liver perfusion scaning performed 1-2 days before operation and a month after postoperation.Intravenous bolus injection of 50 m L nonionic iodinated contrast agent(iopamidol 370mg/m L)at a 5m L/s,then additional saline 50 m Lat a 5m L/s,to get 25 dynamic scans;The spcial perfusion softwarewas used to produce perfusion pseudo-color imaging,lastly,the following quantitative data of BF,BV,TTS,TTP,ALP,PVP,HPI were used to assess the effect of preoperative and postoperative treatment with TACE.Result:The perfusion parameters before operation of 23 cases of HCC are respectively that BF46.10±18.40(m L/100 m L/min),BV12.50±4.32(m L/100 m L),TTS6.06±1.10(S),TTP21.04±3.55(S),ALP 39.30±18.96(m L/100 m L/min),PVP 12.12±7.78(m L/100 m L/min),HPI 78.04±15.74(%).The perfusion parameters after operation of 5 cases HCC which are completely embolized by iodine oil are respectively that BF21.31±6.12(m L/100 m L/min),BV5.10±1.55(m L/100 m L),TTS11.53±1.8 3(S),TTP22.71±4.47(S),ALP14.27±4.09(m L/100 m L/min),PVP48.46±3.74(m L/100 m L/min),HPI 14.82±3.20(%). 18 cases HCC which are partially embolized by iodine oil after operation and the perfusion parameters embolized areas are respectively that BF32.77±14.53(m L/100 m L/min),BV 9.24±6.69(m L/100 m L),TTS8.41±1.45(S),TTP22.44±4.08(S),ALP14.07±3.93(m L/100 m L/min),P VP 83.28±14.80(m L/100 m L/min),HPI 31.58±12.34(%). The perfusion parameters of residual lesion areas of 18 cases HCC which are partially embolized by iodine oil are respectively that BF 46.32±13.08(m L/100 m L/min),BV13.45±8.47(m L/100 m L),TTS5.13±1.31(S),TTP22.10±3.32(S), ALP46.22±12.98(m L/100 m L/min),PVP2.38±0.26(m L/100 m L/min),HPI95.16±17.58(%). For the lesions which are completely embolized by iodine oil, BV,ALP and HPI of the focus of iodine oil completely embolism are lower than preoperation,TTS and PVP are higher,the difference has statistical significance(P<0.05);TTS and PVP of the focus of iodine oil incompletely embolismare higher than preoperation,ALP and HPI are lower,the difference has statistical significance(P<0.05); In the residual lesion area, compared with preoperation, ALP and HPI are higher,PVP is lower, the difference has statistical significance(P<0.05);The parameters in the focus of iodine oil incompletely embolism,compared with the residual lesion area,TTS and PVP are lower(P<0.05), ALP and HPI are clearly higher(P<0.01).Conclution: CT perfusion imaging can be used to evaluate the effection of the TACE and monitor the postoperative residual lesions. |
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