Changes Of Red Blood Cell Distribution Width And Lymphocyte Count In Newly Diagnosed Patients With Systemic Lupus Erythematosus

Background: Due to the backwardness of past medical level, systemic lupus erythematosus(SLE) has been considered as a rare disease. But with the development of medicine, the application of detection means and more and more clearly to know the disease, people found that the disease prevalence is not low. Worldwide prevalence of SLE is about 17/10 million ~48/10 million, and between different countries and regional prevalence rate has a significant difference. In our country is as high as 70/10 million ~75/10 million, more common in women of childbearing age, male to female ratio about 1:10, and the elderly, children also can be sick. SLE has a great harm. In the effect of the environmental, genetic, sex hormones and other aspects, the patients’ immune system is abnormal, and self antigens stimulate the body to produce corresponding antibody, forming immune complex deposited in various tissues and organs, resulting in extensive system damage, and even a threat to life. Therefore, it is very necessary to assess the disease activity in SLE, which is the basis for the evaluation of the severity of the disease, the choice of treatment plan, the evaluation of clinical efficacy and so on. Abroad, there are over 60 disease activity evaluation system for systemic lupus erythematosus all of which combine the complex clinical performance and laboratory examination together as a system of evaluation in patients with each item score, so the operation is complicated.Objective: To study the changes of the red blood cell distribution width(RDW), serum lymphocyte count, eosinophil count in newly diagnosed patients with systemic lupus erythematosus, and the correlation between them and SLE disease activity index(SLEDAI).Methods: 70 patients of newly diagnosed SLE and 41 healthy controls were enrolled, at the same time collecting the red cell distribution width, lymphocyte, eosinophil count and SLE disease activity index. Comparing the difference of the red cell distribution width, eosinophil count level between the two groups with the Chi-Square Test, and analyzing the correlation between the red blood cell distribution width, lymphocyte, eosinophil count and SLE disease activity index.Results: The number of deviants of the RDW(x2=11.599,P =0.001) and eosinophil(x2=45.989,P=0.000) was significantly higher than the control group, and it was statistically significant; In 70 patients of newly diagnosed SLE, the RDW was positively correlated with SLEDAI(r=0.290,P =0.015). The lymphocyte count was negatively correlated with SLEDAI(r=-0.287,P=0.016). No correlation was found between eosinophil count and SLEDAI(r=-0.191,P =0.113).Conclusion: Lymphocyte count and RDW were correlated with the disease activity in newly diagnosed patients with systemic lupus erythematosus.