The Research On Tcm Symptoms Distribution And The Pathogenesis Features Of Perimenopausal Syndrome

Objective:This study investigated and analyzed the clinical characters and TCM symptoms distribution of PS, by collecting information with the four TCM diagnostic methods, in order to further explore the theory and evolvement rules of the pathogenesis, providing a scientific foudation for standardization.Methods:The TCM information table of PS was made, selected and collected PS patients’ information(basic information, symptoms, tongue pictures, pulse conditions, etc.), all the data were analyzed by SPSS 21.0 software. Distribution of TCM symptoms was analyzed, and major syndrome types were selected by cluster analysis, in order to explore the distribution of TCM syndrome types and pathogenesis of PS.Results:1.The onset age of PS concentrates from 46 to 50;2.The jobs with high incidence of PS is administer(18.06%), teacher(15.28%), medical staff(12.50%);3.PS patients’ literacy is mainly college degree or higher(53.70%), middle school degree or less is least(11.57%), and high school to junior school degree is medium(33.80%);4.The frequent symptoms of PS are hot flushes, sweating(87.04%), soreness and weakness of waist and knees(75.93%), dizziness and tinnitus(61.11%), feverishness in palms and soles(60.19%), irritability(57.41%), insomnia and dreaminess(52.31%);5.This study collected 216 case of PS patients, six main types of PS was obtained by cluster analysis as follow:liver-kidney yin deficiency type 58 cases(26.85%), liver depression of the fire type 36 cases(16.67%), imbalance between heartyang and kidney-yin type 33cases(15.28%),insufficiency of both the spleen and the kidney type 21 cases(9.72%), phlegm stagnation type 30cases(13.89%), phlegm and blood stasis type 38 cases(17.59%);6.Difference is statistically significant between age groups of the six PS types(P<0.05),liver-kidney yin deficiency type is the most common during age of 46 to 50(occupied 53.45%),which significantly decreases with increasing age; both the spleen and the kidney type, phlegmstagnation type, phlegm and blood stasis type are most common after age of 50, and increasing with age.Conclusions:1.The most frequent onset age of PS is from 46 to 50, the jobs with high incidence of PS is administer, teacher, medical staff, with improvement of the education degree of the society, the amount of PS patients will increase;2.The symptoms of PS varies, and the disease is intermingled with deficiency and excess.asthenia syndromes refer to yin deficiency type and yang deficiency type, and sthenic syndromes refer to phlegm, dampness, heat, stagnation, blood stasis, eventually form the deficiency, excess,cold, heat mixed and comprehensive lesions;3.Liver-kidney yin deficiency type, liver depression of the fire type, imbalance between heartyang and kidney-yin type, insufficiency of both the spleen and the kidney type are the common frequent type of PS. However, phlegm stagnation type, phlegm and blood stasis type are the more detailed types forms, based on the pathogenesis of liver-kidney yin deficiency, which is the most frequent type, diseased viscera involves liver, heart, spleen, with the production of phlegm, dampness, hyperactivity of yang, heat, Qi depression, blood stasis;4.Age is one of factors that make syndrome elements of PS correlate and evolve, liver-kidney yin deficiency type is the most common at the age of 46~50, with the age increases, heat symptoms decrease, while asthenia syndrome elements(including kidney deficiency and spleen deficiency), and sthenic syndrome elements(including Qi stagnation, phlegm, dampness, blood stasis) goes up.