The Expression And Significance Of Angiopoietin-2 And Glucose Regulated Protein78 In Colorectal Cancer

Colorectal cancer(CRC) is a severe health problem all over the world. To detect expression of Angiopoietin-2(Ang-2) and Glucose Regulated Protein78(GRP78) in colorectal carcinoma tissues, and their correlation with clinical pathological features, we examine expression of Ang-2 and GRP78 by immunohistochemical staining of paraffinembedded tumor specimens from 70 colorectal cancer patients who underwent curative surgery at Qingdao Central Hospital. Through this experiment, the correlation of Ang-2 and GRP78 expression with clinicopathological parameters were analyzed. Ang-2 and GRP78 expression was detected in 68.57% and 74.29% of colorectal carcinoma respectively, significantly higher than the positive rate of normal tissues(P<0.05). Expression of Ang-2 and GRP78 were highly related to differentiation degree, lymph node metastasis, and clinical stages(P<0.05), but no significant correlation to the patients’ age, gender or the site and size of the lump was detected(P>0.05). In addition, Ang-2 and GRP78 expression was positively correlated, but not statistically significant. Ang-2 and GRP78 are over-expressed in colorectal cancer, and may play an important role in the development and progression of colorectal cancer. They could be the molecular markers for judging the malignant degree and infiltration metastasis of colorectal cancer, and provide new targets for targeted therapy of colorectal cancer.