Association Between High-sensitivity Cardiac Troponin T And Incidence Of Atrial Fibrillation Among Patients With Stable Coronary Artery Disease

Objective : To determine the association between plasma high-sensitivity cardiac troponin T(hs-c TnT) levels in patients with stable coronary artery disease(CAD) and the incidence of atrial fibrillation(AF).Methods:Patients with stable CAD, accompanied with the hs-cTn T levels, hospitalized in the geriatric department at the second affiliated hospital of Chongqing medical university from 2013 Jan to 2013 Sep were recruited in this analysis(n=1011).The influence of AF on hs-cTn T levels and the relationships between the circulating levels of hs-cTn T and the incidence of AF were analyzed.Results : A total of 127 patients were diagnosed with AF(12.6%).There were higher circulating levels of hs-cTn T in stable CAD patients with AF than those in patients with stable CAD lonely[17.0(12.0,25.0) ng/L vs 10.0(7.0,13.0) ng/L,P<0.01].The proportion of hs-c Tn T≥14ng was higher in stable CAD patients with AF[70.9%(90/127) vs 24.2%(214/884),P<0.01]. Additionally, the patients with stable CAD were divided into four groups according to the hs-cTn T quartiles, the relative risks for AF were significantly elevated along with the increasing hs-cTnT quartiles(P<0.01 for trend).The ROC curve analyses revealed that the best cut-off value for hs-cTn T to predict AF in stable CAD patients was 13.5ng/L(sensitivity 70.9%, specificity 75.8%;and AUC 0.768, P<0.01). Finally, stepwise multiple logistic regression analysis revealed that the adjusted odds ratio of AF for hs-cTnT≥13.5ng/L was 4.885(95%CI: 2.758-8.652;P<0.01)after adjustment for common risk factors.Conclusions:The hs-cTn T levels were greater in stable CAD patients with AF, and the elevations of hs-c Tn T were an independent predictor of the incidence of AF.