| Objective: To find the changes of the BOLD signal of vetibular function related areas in the normal human and vestibular migraine patients’ brain after vestibular ice water stimulation with resting-state f MRI based on Re Ho、ALFF and f ALFF, to discuss the feasibility of resting-state f MRI technology in study of vestibular cortex function localization, and further evaluate the abnormal change of vestibular central function in vestibular migraine patients.Subjects and Methods: 28 cases of normal people, 12 patients with vestibular migraine, collecting basic information and clinical history, all patients underwent caloric test of vestibular function test. Conduct vestibular stimulation on all subjects(injecting 10 ml 0℃ water into the left and right side external auditory canal of the participants in 10 seconds successively, the interval of both sides is 15min) The subjects’ BOLD resting state of brain function imaging data were collected by using echo planar imaging and 32 channel head coil, data was preprocessed using Mat Lab 7.1 and SPM 8, which was analyzed in order to obtain the Re Ho, ALFF and f ALFF images using REST 1.4 software. For the normal control group, the standardization of Re Ho, ALFF and f ALFF parameter mapping of the resting state and after stimulation was performed paired T test group analysis based on general linear model using SPM8 statistical modules, to confirm the activity of related brain regions in normal control group after ice water vestibular stimulation; the control group and vestibular migraine patients group were analyzed with two samples T test group analysis,to confirm the abnormal function brain regions in vestibular migraine. Results: 1) Re Ho, ALFF and f ALFF images of normal control group appeared activated increase or decrease of multiple brain regions after vestibular ice water stimulation, the 3 parameter value increased or activated brain regions are mainly located in the insular cortex, superior temporal gyrus, hippocampus, parahippocampal gyrus, brainstem, thalamus, basal ganglia, cerebellum hemisphere, decreased or negative activated brain areas are mainly located in the occipital gyrus, middle frontal gyrus, inferior frontal gyrus, transverse temporal gyrus, inferior parietal lobule, the precuneus, postcentral gyrus etc;2) The brain regions of increased signal in patientswith vestibular migraine group than the normal control mainly includes: the brainstem, temporal gyrus, middle temporal gyrus, medial frontal gyrus, inferior parietal lobule, postcentral gyrus, limbic lobe; brain regions of decreased signal mainly include: the cerebellum and occipital gyrus, inferior temporal gyrus, superior temporal gyrus, insular lobe, basal ganglia and thalamus, frontal cortex, the precuneus, anterior cingulated etc.Conclusion: 1) This study carried vestibular stimulation with 0℃ water to induce vestibular vertigo, and undergo resting-state f MRI imaging which based on three parameters Re Ho, ALFF, f ALFF, confirm humans have widespread cortical and subcortical network system involved in vestibular signal processing, including the insular cortex, superior temporal gyrus, hippocampus, parahippocampal gyrus, brainstem, thalamus, basal ganglia, cerebellum hemisphere etc, the three kinds of parameters have good consistency, have the ability to position the vestibular function brain areas.2) The vestibular central function and peripheral vestibular function of patients with vestibular migraine were both abnormal, the resting-state f MRI method have certain value for the research of central vestibular system in vestibular migraine, vestibular function examination techniques can be combined with the f MRI used in the diagnosis and research of vestibular migraine and vestibular related diseases. |
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